Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis
Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis
复制标题
DOI：
10.1007/s00234-010-0653-1
复制
发表时间：
2010-08-01
期刊：
影响因子：
2.8
通讯作者：
Tsuji, Shoji
中科院分区：
文献类型：
--
作者：
Sato, Kanako;Aoki, Shigeki;Tsuji, Shoji
The uncinate fasciculus (UF) consists of core fibers connecting the frontal and temporal lobes and is considered to be related to cognitive/behavioral function. Using diffusion tensor tractography, we quantitatively evaluated changes in fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) of the UF by tract-specific analysis to evaluate the damage of the UF in patients with amyotrophic lateral sclerosis (ALS).We obtained diffusion tensor images of 15 patients with ALS and 9 age-matched volunteers.Patients with ALS showed significantly lower mean FA (P = 0.029) compared with controls. No significant difference was seen in mean ADC.The results suggest that damage of the UF in patients with ALS can be quantitatively evaluated with FA.
