Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis
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DOI：
10.1128/jb.01988-07
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发表时间：
2008-07-01
影响因子：
3.2
通讯作者：
Berisio, Rita
中科院分区：
文献类型：
--
作者：
Esposito, Carla;Pethoukov, Maxim V.;Berisio, Rita
肝素结合血凝素（HBHA）是结核病的毒力因子，负责肺外传播。HBHA的彻底生化表征提供了HBHA盘绕性质的实验证据。这些数据，以及通过小角度x射线散射获得的HBHA全长形式和截断形式的低分辨率结构，明确表明HBHA具有细长形状的二聚体结构。
Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.