Trapping and identifying single-nanoparticles using a low-aspect-ratio nanopore
Trapping and identifying single-nanoparticles using a low-aspect-ratio nanopore
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DOI：
10.1063/1.4813084
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发表时间：
2013-07-01
影响因子：
4
通讯作者：
Taniguchi, Masateru
中科院分区：
文献类型：
--
作者：
Tsutsui, Makusu;Maeda, Yoichi;Taniguchi, Masateru
流体中颗粒和分子的操纵是生物传感器的一项基本技术。在这里，我们报告了使用低纵横比纳米孔对单纳米粒子的电捕获和识别。通过控制跨膜电泳电压来实现粒子捕获和去捕获。人们发现，这种电方法能够凭借静电和电渗力这两个抵消因素之间的平衡，将单个纳米颗粒放置在光刻限定的纳米孔附近。我们还证明了通过粒子-孔间隙空间的离子电流来识别捕获的纳米粒子。该技术可能会在电极嵌入的纳米孔传感器中得到应用。 (C) 2013 AIP 出版有限责任公司。
Manipulation of particles and molecules in fluid is a fundamental technology in biosensors. Here, we report electrical trapping and identification of single-nanoparticles using a low-aspect-ratio nanopore. Particle trapping and detrapping are implemented through a control of the cross-membrane electrophoretic voltage. This electrical method is found to enable placing an individual nanoparticle in vicinity of a lithographically-defined nanopore by virtue of the balance between the two counteracting factors, electrostatic and electroosmotic forces. We also demonstrate identification of trapped nanoparticles by the ionic current through the particle-pore gap space. This technique may find applications in electrode-embedded nanopore sensors. (C) 2013 AIP Publishing LLC.