A trial-based experimental design for fMRI
A trial-based experimental design for fMRI
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DOI：
10.1006/nimg.1997.0279
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发表时间：
1997-08-01
期刊：
影响因子：
5.7
通讯作者：
DEsposito, M
中科院分区：
文献类型：
--
作者：
Zarahn, E;Aguirre, G;DEsposito, M
功能性磁共振成像（fMRI）的实验设计，其分析的概念单位是行为试验，在对比试验块。这种类型的设计被称为基于试验（TB）的fMRI设计。解释了TB设计如何能够提供以下能力：（1）随机化行为试验的呈现，以及（2）利用不受控制的行为测量中的试验间方差来检查其功能相关性。描述了一种特定类型的TB设计，其涉及用一个或多个移位脉冲响应函数对试验诱发的fMRI响应进行建模。该设计能够区分在试验中时间上分离的行为子成分期间发生的功能变化，实现了这样的设计的一个例子，并测试了其统计特异性、功能灵敏度和功能特异性。(C)北京：科学出版社.
An experimental design for functional MRI (fMRI) is presented whose conceptual units of analysis are behavioral trials, in contrast to blocks of trials. This type of design is referred to as a trial-based (TB) fMRI design. It is explained how TB designs can afford the ability to: (1) randomize the presentation of behavioral trials and (2) utilize intertrial variance in uncontrolled behavioral measures to examine their functional correlates, A particular type of TB design that involves modeling trial-evoked fMRI responses with one or more shifted impulse response functions is described. This design is capable of discriminating functional changes occurring during temporally separated behavioral subcomponents within trials, An example of such a design is implemented and its statistical specificity, functional sensitivity and functional specificity are tested. (C) 1997 Academic Press.