Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods
Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods
复制标题
利用超低剂量铁氧体八足体对原位和转移性肝肿瘤进行灵敏对比增强磁共振成像
DOI：
10.1021/acs.chemmater.8b04760
复制
发表时间：
2019
影响因子：
8.6
通讯作者：
Gao Jinhao
中科院分区：
文献类型：
--
作者：
Yang Lijiao;Sun Chengjie;Lin Hongyu;Gong Xuanqing;Zhou Tiantian;Deng Wen-Ting;Chen Zhong;Gao Jinhao
磁性纳米颗粒（MNPs）的对比能力对于磁共振成像（MRI）对肿瘤的敏感和准确诊断至关重要。然而，目前的对比剂（CAs）的低灵敏度仍然是满足临床需要的主要限制。形状工程和组成工程是提高MNPs对比度的两种重要手段。在此，我们报告了一种简便的方法，结合这两种方法来制造具有大有效半径和各种锌掺杂比的铁酸锌八足体。随着锌掺杂水平的提高，这些八足体的饱和磁化率和T2弛豫率都呈现出一个有趣的趋势。特别是，ZnxFe3-xO4 （x = 0.44）在7.0 T下的r2值为989.1 mM-1s-1，是迄今为止报道的最高T2弛豫率，是Feraheme的10.2倍。在这个八足样本的帮助下，对比增强MRI （CE-MRI）检测原位和转移性肝肿瘤可以完成。
Contrast ability of magnetic nanoparticles (MNPs) is critical for the sensitive and accurate diagnosis of cancer with magnetic resonance imaging (MRI). However, the low sensitivity of current contrast agents (CAs) remains a major limitation to meet clinical needs. Shape and composition engineering are two important means for improving the contrast ability of MNPs. Herein, we report a facile method incorporating both approaches to manufacture zinc ferrite octapods with a large effective radius and various Zn doping ratios. The saturated magnetizations and T2 relaxivities of these engineered octapods both show an interesting trend with ascending zinc doping level. Particularly, the r2 value of ZnxFe3–xO4 (x = 0.44) octapods at 7.0 T is 989.1 mM–1s–1, and the highest T2 relaxivity ever reported, which is 10.2 times higher than the commercial sample, Feraheme. With the aid of this octapod sample, contrast-enhanced MRI (CE-MRI) for detecting orthotopic and metastatic hepatic tumors could be accomplished even a...