GENETICS OF NATURAL-RESISTANCE TO HERPES-SIMPLEX VIRUS TYPE-1 LATENT INFECTION OF THE PERIPHERAL NERVOUS-SYSTEM IN MICE
GENETICS OF NATURAL-RESISTANCE TO HERPES-SIMPLEX VIRUS TYPE-1 LATENT INFECTION OF THE PERIPHERAL NERVOUS-SYSTEM IN MICE
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DOI：
10.1099/0022-1317-67-4-613
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发表时间：
1986-04-01
影响因子：
3.8
通讯作者：
PUTERMAN, ML
中科院分区：
文献类型：
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作者：
KASTRUKOFF, LF;LAU, AS;PUTERMAN, ML
对唇部接种 1 型单纯疱疹病毒 (HSV-1) 的小鼠的三叉神经节中潜在感染的自然抵抗力的遗传学进行了检查。根据与菌株和 HSV-1 浓度相关的潜伏期的逻辑回归系数，近交系小鼠形成了从最耐药 (C57BL/6J) 到最易感 (PL/J) 的连续耐药性。当对这些结果以及使用非致命浓度的 HSV-1 研究得出的潜伏期数据进行分析时，在这些菌株中鉴定出三个亚群：耐药（C57BL/10J、BALB/cByJ、C57BL/6J）、中度耐药（DBA/2J、SWR/J、A/J、AKR/J、DBA/1J）和易感（PL/J、LP/J、CBA/J）。抗性和中度抗性菌株（B6D2F1/J，B6AF1/J）之间以及抗性和敏感菌株之间的F1杂交结果[（C57BL/6J×CBA/J）F1（C57BL/6J×LP/J）F10]表明抗性占主导地位。来自近交系和同类系的数据均未能显示 H-2 与对潜伏感染发展的抗性之间的关联。死亡率研究还表明存在连续体，C57BL/10J、C57BL/6J 和 DBA/1J 更具有抵抗力，而 PL/J 小鼠最易受影响。当根据对潜伏感染发展的抵抗力和死亡率对近交株进行分类时，可以识别出五组。 A 组是对死亡和潜伏期均具有抗性的菌株（C57BL/6J、C57BL/10J、DBA/1J），而 B 组由一种对死亡具有中等抗性但对潜伏期具有抗性的菌株 (BALB/cByJ) 组成。 C组是对死亡具有中等抵抗力且对潜伏期敏感的菌株(LP/J、CBA/J)，而D组是对死亡敏感且对潜伏期敏感度中等的菌株(AKR/J、SWR/J、DBA/2J)。 E 组由一种对死亡率和潜伏期敏感的菌株 (PL/J) 组成。这些结果表明宿主因素在体内潜伏感染的建立中发挥着重要作用。
The genetics of natural resistance to the development of latent infection in the trigeminal ganglia of mice inoculated in the lip with herpes simplex virus type 1 (HSV-1) was examined. Based on coefficients of a logistic regression relating latency to strain and HSV-1 concentration, inbred strains of mice formed a continuum of resistance ranging from most resistant (C57BL/6J) to most susceptible (PL/J). When these results were analysed along with latency data derived from studies employing a non-fatal concentration of HSV-1, three subpopulations were identified among these strains: resistant (C57BL/10J, BALB/cByJ, C57BL/6J), moderately resistant (DBA/2J, SWR/J, A/J, AKR/J, DBA/1J) and susceptible (PL/J, LP/J, CBA/J). Results from F1 hybrids between resistant and moderately resistant strains (B6D2F1/J, B6AF1/J) and between resistant and susceptible strains [(C57BL/6J .times. CBA/J)F1 (C57BL/6J .times. LP/J)F10] indicated that resistance is dominant. Data from both inbred and congenic strains failed to show an association between H-2 and resistance to the development of a latent infection. Studies of mortality also indicated that a continuum was present, with C57BL/10J, C57BL/6J and DBA/1J being more resistant and PL/J mice most susceptible. When inbred strains were categorized on the basis of resistance to the development of latent infection and mortality, five groups could be identified. Group A are strains resistant to both mortality and latency (C57BL/6J, C57BL/10J, DBA/1J) while group B consists of one strain (BALB/cByJ) intermediate in resistance to mortality but resistant to latency. Group C are strains intermediate in resistance to mortality and susceptible to latency (LP/J, CBA/J) while Group D are strains susceptible to mortality and intermediate in susceptibility to latency (AKR/J, SWR/J, DBA/2J). Group E consists of one strain (PL/J) susceptible to both mortality and latency. These results indicate that host factors play an important role in the establishment of latent infection in vivo.