Inhibition of ENaC by endothelin-1.
Inhibition of ENaC by endothelin-1.
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DOI：
10.1016/bs.vh.2015.01.001
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发表时间：
2015
影响因子：
--
通讯作者：
Staruschenko A
中科院分区：
文献类型：
--
作者：
Sorokin A;Staruschenko A
The amiloride-sensitive epithelial Na+ channel (ENaC) is a key player in the regulation of Na+ homeostasis. Its functional activity is under continuous control by a variety of signaling molecules including bioactive peptides of endothelin family. Since ENaC dysfunction is causative for disturbances in total body Na+ levels associated with abnormal regulation of blood volume, blood pressure, and lung fluid balance, the uncovering the molecular mechanisms of inhibitory modulation or inappropriate activation of ENaC is crucial for the successful treatment of a variety of human diseases including hypertension. The precise regulation of ENaC is particularly important for normal Na+ and fluid homeostasis in organs where endothelins are known to act: kidneys, lung and colon. Inhibition of ENaC by endothelin-1 (ET-1) has been established in renal cells and several molecular mechanisms of inhibition of ENaC by ET-1 are proposed and will be reviewed in this chapter.
