Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age.
Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age.
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血液铅浓度<10 microg/dl和6岁的儿童智力。
DOI：
10.1289/ehp.10424
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发表时间：
2008-02
影响因子：
10.4
通讯作者：
Canfield, Richard L.
中科院分区：
文献类型：
--
作者：
Jusko, Todd A.;Henderson, ChaKes R., Jr.;Lanphear, Bruce P.;Cory-Slechta, Deborah A.;Parsons, Patrick J.;Canfield, Richard L.
很少有研究提供与血铅浓度< 10微克/分升是否会对儿童的认知功能产生不利影响的问题直接相关的数据。我们研究了儿童早期血铅浓度与儿童6岁时智商之间的关系。对6个月至6岁的儿童进行随访，并在6、12、18和24个月以及3、4、5和6岁时测定血铅浓度。在6岁时，智力进行了评估，在194名儿童使用韦氏学龄前和小学智力量表修订版。我们使用一般线性和半参数模型来估计和检验血铅浓度与智商之间的关联。在调整了母亲的智商、HOME量表评分和其他潜在的混杂因素后，终生平均血铅浓度（平均值= 7.2 μg/dL;中位数= 6.2 μg/dL）与全面智商（p = 0.006）和操作智商（p = 0.002）呈负相关。与终生平均血铅浓度< 5 μg/dL的儿童相比，终生平均血铅浓度在5 μg/dL和9.9 μg/dL之间的儿童在全面智商上得分低4.9分（91.3 vs. 86.4，p = 0.03）。峰值血铅浓度的非线性模型显示峰值血铅水平与全量表智商之间呈负相关（p = 0.003），最低为2.1 μg/dL，这是我们研究中观察到的最低峰值血铅浓度。来自该队列的证据表明，6岁儿童的智力功能因血铅浓度远低于10 μg/dL而受损，这是疾病控制和预防中心对血铅水平升高的定义。
Few studies provide data directly relevant to the question of whether blood lead concentrations < 10 μg/dL adversely affect children’s cognitive function. We examined the association between blood lead concentrations assessed throughout early childhood and children’s IQ at 6 years of age. Children were followed from 6 months to 6 years of age, with determination of blood lead concentrations at 6, 12, 18, and 24 months, and 3, 4, 5, and 6 years of age. At 6 years of age, intelligence was assessed in 194 children using the Wechsler Preschool and Primary Scale of Intelligence–Revised. We used general linear and semiparametic models to estimate and test the association between blood lead concentration and IQ. After adjustment for maternal IQ, HOME scale scores, and other potential confounding factors, lifetime average blood lead concentration (mean = 7.2 μg/dL; median = 6.2 μg/dL) was inversely associated with Full-Scale IQ (p = 0.006) and Performance IQ scores (p = 0.002). Compared with children who had lifetime average blood lead concentrations < 5 μg/dL, children with lifetime average concentrations between 5 and 9.9 μg/dL scored 4.9 points lower on Full-Scale IQ (91.3 vs. 86.4, p = 0.03). Nonlinear modeling of the peak blood lead concentration revealed an inverse association (p = 0.003) between peak blood lead levels and Full-Scale IQ down to 2.1 μg/dL, the lowest observed peak blood lead concentration in our study. Evidence from this cohort indicates that children’s intellectual functioning at 6 years of age is impaired by blood lead concentrations well below 10 μg/dL, the Centers for Disease Control and Prevention definition of an elevated blood lead level.
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影响因子：
158.5
作者：
BAGHURST, PA;MCMICHAEL, AJ;TONG, SL
通讯作者：
TONG, SL
影响因子：
8
作者：
Bernard, SM;McGeehin, MA
通讯作者：
McGeehin, MA
影响因子：
158.5
作者：
Canfield, RL;Henderson, CR;Lanphear, BP
通讯作者：
Lanphear, BP
影响因子：
10.4
作者：
Hu H;Téllez-Rojo MM;Bellinger D;Smith D;Ettinger AS;Lamadrid-Figueroa H;Schwartz J;Schnaas L;Mercado-García A;Hernández-Avila M
通讯作者：
Hernández-Avila M
影响因子：
4.6
作者：
Bradley, RH;Corwyn, RF;Coll, CG
通讯作者：
Coll, CG