myo-Inositol-1,2,3,4,5,6-hexakisphosphate
myo-Inositol-1,2,3,4,5,6-hexakisphosphate
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DOI：
10.1016/s0031-9422(03)00446-1
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发表时间：
2003-11-01
期刊：
影响因子：
3.8
通讯作者：
Raboy, V
中科院分区：
文献类型：
--
作者：
Raboy, V
肌醇-1，2，3，4，5，6-六烷基磷酸(Ins P-6)是植物种子和其他植物组织中的一种丰富的磷形式，被称为植酸。随后发现它是真核细胞中的一种常见成分，其代谢是细胞管家的基本成分。除了磷酸盐、肌醇(INS)和植物器官和组织中矿物质的储存和回收外，INS-6的其他作用还包括作为INS磷酸盐和焦磷酸盐途径的主要代谢池，参与信号和调控；可能作为这些过程的效应器或配体；作为一种形式的能量货币和ATP再生；在RNA输出和DNA修复；以及作为抗氧化剂。较新的证据表明，INS P-6的焦磷酸衍生物可以作为磷酸供体在ATP的再生中发挥作用，这让人想起40年前在种子发育研究中提出的INS P-6本身可能起到这一作用的建议。在非植物系统中对INS P-6的研究很少包括这种化合物可能代表细胞P的一个重要部分的考虑；细胞磷营养一直被认为不感兴趣或重要性不大。然而，在涉及INS P-6的代谢途径以及INS及其代谢物的可能作用范围方面，不同的真核生物之间可能几乎没有根本的区别。爱思唯尔有限公司出版。
myo-Inositol-1,2,3,4,5,6-hexakisphosphate (Ins P-6) was first described as an abundant form of phosphorus in plant seeds and other plant tissues and dubbed "phytic acid". Subsequently it was found to be a common constituent in eukaryotic cells, its metabolism a basic component of cellular housekeeping. In addition to phosphate, myo-inositol (Ins) and mineral storage and retrieval in plant organs and tissues, other roles for Ins P-6 include service as a major metabolic pool in Ins phosphate and pyrophosphate pathways involved in signaling and regulation; possibly as an effector or ligand in these processes; as a form of energy currency and in ATP regeneration; in RNA export and DNA repair; and as an anti-oxidant. The relatively recent demonstration that pyrophosphate-containing derivatives of Ins P-6 can function as phosphate donors in the regeneration of ATP is reminiscent of the proposal, made four decades ago in studies of seed development, that Ins P-6 itself may serve in this function. Studies of Ins P-6 in non-plant systems rarely include the consideration that this compound might represent a significant fraction of cellular P; cellular phosphate nutrition has been viewed as either not interesting or of little importance. However, there may be few fundamental differences among diverse eukaryotes in both the metabolic pathways involving Ins P-6 and the spectrum of possible roles for it and its metabolites. Published by Elsevier Ltd.