Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma.
Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma.
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DOI：
10.1038/bcj.2017.70
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发表时间：
2017-08-25
影响因子：
12.8
通讯作者：
Cerhan JR
中科院分区：
文献类型：
--
作者：
Tracy SI;Maurer MJ;Witzig TE;Drake MT;Ansell SM;Nowakowski GS;Thompson CA;Inwards DJ;Johnston PB;Micallef IN;Allmer C;Macon WR;Weiner GJ;Slager SL;Habermann TM;Link BK;Cerhan JR
We evaluated whether vitamin D insufficiency (VDI; 25(OH)D <20 ng/ml) was associated with adverse outcomes among follicular lymphoma (FL) patients using an observational prospective cohort study of 642 FL patients enrolled from 2002–2012. The median age at diagnosis was 60 years. At a median follow-up of 59 months, 297 patients (46%) had an event (progression, treatment failure), 78 had died and 42 (6.5%) had a lymphoma-related death. VDI was associated with inferior event-free survival (EFS) at 12 months (EFS12, odds ratio (OR)=2.05; 95% confidence interval (CI) 1.18–3.54), overall survival (OS, hazards ratio (HR)=2.35; 95%CI 1.37–4.02), and lymphoma-specific survival (LSS, HR=2.97; 95% CI 1.52–5.80) for the full cohort. Among patients treated with immunochemotherapy (IC), VDI was associated with inferior EFS12 (OR=3.00; 95% CI 1.26–7.13), OS (HR=2.86; 95% CI 1.39–5.85), and LSS (HR=2.96; 95% CI 1.29–6.79). For observed patients, VDI was associated with inferior OS (HR=2.85; 95% CI 1.20–6.76). For other therapies, VDI was associated with inferior OS (HR=3.06; 95% CI 1.01–9.24). Our work is the first to reveal an association of VDI with early clinical failure, and to demonstrate an association of VDI with adverse outcomes among patients who are observed or treated with therapies other than IC. Our findings suggest a potentially modifiable prognostic factor to address in patients with FL.
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影响因子：
12.8
作者：
Maurer, Matthew J.;Bachy, Emmanuel;Ghesquieres, Herve;Ansell, Stephen M.;Nowakowski, Grzegorz S.;Thompson, Carrie A.;Inwards, David J.;Allmer, Cristine;Chassagne-Clement, Catherine;Nicolas-Virelizier, Emmanuelle;Sebban, Catherine;Lebras, Laure;Sarkozy, Clementine;Macon, William R.;Feldman, Andrew L.;Syrbu, Sergei I.;Traverse-Glehan, Alexandra;Coiffier, Bertrand;Slager, Susan L.;Weiner, George J.;Witzig, Thomas E.;Habermann, Thomas M.;Salles, Gilles;Cerhan, James R.;Link, Brian K.
通讯作者：
Link, Brian K.
影响因子：
45.3
作者：
Kelly, Jennifer L.;Salles, Gilles;Friedberg, Jonathan W.
通讯作者：
Friedberg, Jonathan W.
在抗 CD20 抗体免疫治疗期间，先天单核吞噬细胞网络通过 Fc 受体依赖性机制耗尽 B 淋巴细胞。
DOI：
10.1084/jem.20040119
发表时间：
2004-06-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Uchida J;Hamaguchi Y;Oliver JA;Ravetch JV;Poe JC;Haas KM;Tedder TF
通讯作者：
Tedder TF
影响因子：
12.8
作者：
Ng, Alvin C.;Kumar, Shaji K.;Rajkumar, S. Vincent;Drake, Matthew T.
通讯作者：
Drake, Matthew T.
影响因子：
45.3
作者：
Bittenbring, Joerg Thomas;Neumann, Frank;Pfreundschuh, Michael
通讯作者：
Pfreundschuh, Michael