mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.
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DOI：
10.1038/s41591-021-01676-0
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发表时间：
2022-03
期刊：
影响因子：
82.9
通讯作者：
Klein F
中科院分区：
文献类型：
--
作者：
Gruell H;Vanshylla K;Tober-Lau P;Hillus D;Schommers P;Lehmann C;Kurth F;Sander LE;Klein F
SARS-CoV-2的欧米克龙变种正导致全球感染人数迅速增加。这种令人担忧的新变种在病毒尖峰糖蛋白上的中和抗体的关键表位上携带着异常多的突变，这表明可能的免疫逃避。在这里，我们评估了接种疫苗和康复个体的纵向队列中的血清中和能力，以及使用假病毒中和试验检测针对奥美康的单抗活性。我们报告了在接种了两剂BNT162b2新冠肺炎疫苗的患者和康复患者的多克隆血清中几乎完全缺乏中和奥米克隆的活性，以及临床使用中对不同单抗的抵抗力。然而，在疫苗接种和恢复期的个体中，mRNA加强免疫可显著提高血清中和奥美康的活性。这项研究表明，加强免疫可以关键地改善针对Omicron变体的体液免疫反应。在两剂新冠肺炎疫苗BNT162b2的接受者或恢复者的血清中，SARS-CoV-2 Omicron变体的中和能力明显受损，但在加强疫苗剂量后，这两组患者的中和能力都显著增强。
The Omicron variant of SARS-CoV-2 is causing a rapid increase in infections across the globe. This new variant of concern carries an unusually high number of mutations in key epitopes of neutralizing antibodies on the viral spike glycoprotein, suggesting potential immune evasion. Here we assessed serum neutralizing capacity in longitudinal cohorts of vaccinated and convalescent individuals, as well as monoclonal antibody activity against Omicron using pseudovirus neutralization assays. We report a near-complete lack of neutralizing activity against Omicron in polyclonal sera from individuals vaccinated with two doses of the BNT162b2 COVID-19 vaccine and from convalescent individuals, as well as resistance to different monoclonal antibodies in clinical use. However, mRNA booster immunizations in vaccinated and convalescent individuals resulted in a significant increase of serum neutralizing activity against Omicron. This study demonstrates that booster immunizations can critically improve the humoral immune response against the Omicron variant. Neutralization of the SARS-CoV-2 Omicron variant is markedly impaired in sera from recipients of two doses of the COVID-19 vaccine BNT162b2 or from convalescent individuals, but is robustly increased in both groups following a booster vaccine dose.
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影响因子：
64.5
作者：
Sette A;Crotty S
通讯作者：
Crotty S
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
17.1
作者：
Jones BE;Brown-Augsburger PL;Corbett KS;Westendorf K;Davies J;Cujec TP;Wiethoff CM;Blackbourne JL;Heinz BA;Foster D;Higgs RE;Balasubramaniam D;Wang L;Zhang Y;Yang ES;Bidshahri R;Kraft L;Hwang Y;Žentelis S;Jepson KR;Goya R;Smith MA;Collins DW;Hinshaw SJ;Tycho SA;Pellacani D;Xiang P;Muthuraman K;Sobhanifar S;Piper MH;Triana FJ;Hendle J;Pustilnik A;Adams AC;Berens SJ;Baric RS;Martinez DR;Cross RW;Geisbert TW;Borisevich V;Abiona O;Belli HM;de Vries M;Mohamed A;Dittmann M;Samanovic MI;Mulligan MJ;Goldsmith JA;Hsieh CL;Johnson NV;Wrapp D;McLellan JS;Barnhart BC;Graham BS;Mascola JR;Hansen CL;Falconer E
通讯作者：
Falconer E
mRNA疫苗会诱导SARS-COV-2和关注的变体诱导耐用的免疫记忆。
DOI：
10.1126/science.abm0829
发表时间：
2021-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
32.4
作者：
Muecksch F;Weisblum Y;Barnes CO;Schmidt F;Schaefer-Babajew D;Wang Z;C Lorenzi JC;Flyak AI;DeLaitsch AT;Huey-Tubman KE;Hou S;Schiffer CA;Gaebler C;Da Silva J;Poston D;Finkin S;Cho A;Cipolla M;Oliveira TY;Millard KG;Ramos V;Gazumyan A;Rutkowska M;Caskey M;Nussenzweig MC;Bjorkman PJ;Hatziioannou T;Bieniasz PD
通讯作者：
Bieniasz PD