Obesity, weight change and risks for hypertension, diabetes and hypercholesterolemia in Japanese men
Obesity, weight change and risks for hypertension, diabetes and hypercholesterolemia in Japanese men
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DOI：
10.1038/sj.ejcn.1601364
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发表时间：
2002-07-01
影响因子：
4.7
通讯作者：
Inoue, S
中科院分区：
文献类型：
--
作者：
Ishikawa-Takata, K;Ohta, T;Inoue, S
目的：研究日本男性的体重指数和体重增加程度对高血压、高胆固醇血症和糖尿病的影响，并与高加索人群的相应影响进行比较。设计：前瞻性队列研究。设置：一家公司的所有男性员工队列。受试者：共4737名男性员工，随访至退休或4年结果：体重指数增加超过22 kg/m2与高血压风险增加相关，即使在调整了可能的混杂因素如年龄、吸烟状况、饮酒、家族史和收缩压基线值后也是如此。体重指数高于27 kg/m2的受试者患高血压的风险大大增加，体重指数高于29 kg/m2的受试者患糖尿病和高胆固醇血症的风险大大增加。在调整可能的混杂因素后，体重增加（超过2 kg）与高血压和高胆固醇血症风险增加密切相关。然而，体重增加与糖尿病无关，体重减轻并没有降低任何三种疾病的风险。结论：在日本人中，与高血压，糖尿病和高胆固醇血症风险相关的体重指数的程度低于高加索人。高血压和高胆固醇血症的风险与体重增加在日本男性人口谁表现出低患病率的严重肥胖，和风险类似或略高于那些在白人人口与高患病率的严重肥胖。赞助：健康科学研究基金由日本厚生省。
Objective: To examine the effects of the degree of body mass index and weight gain as the risks for hypertension, hypercholesterolemia and diabetes in Japanese men, and to compare that to the corresponding effects in a Caucasian population.Design: Prospective cohort study.Setting: Cohort of all male employees at a company.Subjects: A total of 4737 male employees followed until retirement or for 4y (longest term 4y).Results: Increase of body mass index beyond 22 kg/m(2) related to an increased risk for hypertension even after being adjusted for possible confounding factors such as age, smoking status, alcohol intake, family history and baseline value of systolic blood pressure. The risks greatly increased in subjects with a body mass index above 27 kg/m(2) for hypertension, and 29 kg/m(2) for diabetes and hypercholesterolemia. Weight gain (more than 2 kg) was strongly related to an increased risk for hypertension and hypercholesterolemia after being adjusted for possible confounding factors. However, weight gain was not related to diabetes, and weight loss did not decrease the risks for any of the three diseases.Conclusions: Among Japanese, the degrees of body mass index associated with risks for hypertension, diabetes and hypercholesterolemia were lower than those in Caucasians. The risks for hypertension and hypercholesterolemia were strongly associated with weight gain in a Japanese male population who showed a low prevalence of severe obesity, and the risks were similar to or somewhat higher than those in a Caucasian population with a high prevalence of severe obesity.Sponsorship: Health Science Research Grant by the Ministry of Health and Welfare of Japan.