Endoscopy-Based in Situ Bulk Video Imaging of Batch Crystallization Processes
Endoscopy-Based in Situ Bulk Video Imaging of Batch Crystallization Processes
复制标题
基于内窥镜的批量结晶过程原位批量视频成像
DOI：
--
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
K. Hungerbühler
中科院分区：
文献类型：
--
作者：
L. L. Simon;Z. Nagy;K. Hungerbühler
结晶过程的外部块体视频成像(EBVI)已被证明是确定亚稳区的一种很有前途的技术。在这篇文章中，介绍了基于内窥镜的原位块状视频成像(IBVI)方法。视频数据使用平均灰度法和数字图像处理技术进行处理，该技术旨在检测成核过程中的第一个晶体。实验是在CRCv4小型量热仪上进行的，在此过程中监测了补偿加热器和红外光谱信号。结果表明，利用平均灰度(MGI)趋势监测表观成核的开始，即具有可检测尺寸的颗粒的形成，其性能与量热和红外光谱信号相似，而晶体识别方法是最快的，可以更早地检测到成核。提出了基于内窥镜的成核监测技术，作为对现有工艺分析技术的补充。
External bulk video imaging (eBVI) of crystallization processes has proven to be a promising technique for metastable zone determination. In this contribution the endoscopy-based in situ bulk video imaging (iBVI) method is introduced. The video data are processed using the mean gray intensity method and by a digital image processing technique which aims to detect the first crystals during nucleation. The experiments have been carried out in a small-scale calorimeter CRCv4, during which the compensation heater and infrared spectroscopy signals were monitored. It is concluded that monitoring the onset of the apparent nucleation, formation of particles with detectable size, using the mean gray intensity (MGI) trend delivers similar performance to the calorimetric and IR spectroscopy signal, whereas the crystal recognition method is the fastest, allowing detection of nucleation earlier. The endoscopy-based nucleation monitoring technique is proposed as a complementary tool to existing process analytical techn...