Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
复制标题
DOI：
10.1016/s0140-6736(00)03231-1
复制
发表时间：
2000-11-25
期刊：
影响因子：
168.9
通讯作者：
Nakachi, K
中科院分区：
文献类型：
--
作者：
Imai, K;Matsuyama, S;Nakachi, K
背景免疫监测中最关键的问题之一是个体之间关于天然免疫宿主防御的差异是否可以预测癌症的未来发展。虽然这个问题至今仍悬而未决，但有明确的迹象表明，几种天然细胞毒性淋巴细胞在预防癌症发展中具有重要作用。我们在1986年开始了一项前瞻性队列研究，在日本一般人群中，使用各种免疫学和生化markers.Methods自然的外周血单核细胞的细胞毒活性进行了评估同位素释放试验在3625居民的日本人口大多年龄超过40岁，1986年和1990年之间。还测量了免疫学和生化标志物，并向参与者提供了一份关于生活方式的问卷。我们做了一个II年的随访调查的队列成员在癌症发病率和死亡的所有原因，并分析了外周血淋巴细胞的细胞毒活性之间的关联评估基线和癌症发病率发现在随后的follow-up.Findings 154癌症病例中使用的分析。当我们按三分位数对外周血淋巴细胞的细胞毒活性进行分类时，以低细胞毒活性的风险为参考，高细胞毒活性男性的年龄校正癌症发病率相对风险（所有部位）为0.72（95%CI 0.45-1.16），中等细胞毒活性男性为0.62（0.38-1.03）。对于具有高细胞毒活性的女性，相对风险为0.52（0.28-0.95），对于具有中等细胞毒活性的女性，相对风险为0.56（0.31-1.01）。对于具有高和中等细胞毒性活性的两种性别，风险为0.63（0.43-0.92）和0.59（0.40-0.87）。解释我们的结果表明，外周血淋巴细胞的中等和高细胞毒活性与癌症风险的降低有关，而低活性与增加的癌症风险相关，表明天然免疫宿主防御机制对癌症的作用。
Background One of the most critical questions in immunosurveillance is whether differences between individuals with regards to natural immunological host defence can predict future development of cancer. Although this question has so far remained open, there are clear indications of significant roles of several naturally cytotoxic lymphocytes in preventing the development of cancer. We began a prospective cohort study among a Japanese general population in 1986, using various immunological and biochemical markers.Methods Natural cytotoxic activity of peripheral-blood mononuclear cells was assessed by isotope-release assay in 3625 residents of a Japanese population mostly older than 40 years of age, between 1986 and 1990. Immunological and biochemical markers were also measured, and participants were given a questionnaire on lifestyle. We did an Ii-year follow-up survey of the cohort members looking at cancer incidence and death from all causes, and analysed the association between cytotoxic activity of peripheral-blood lymphocytes assessed at baseline and cancer incidence found in the subsequent follow-up.Findings 154 cancer cases were used in the analysis. When we categorised the cytotoxic activity of peripheral-blood lymphocytes by tertiles, age-adjusted relative risk of cancer incidence (all sites) was 0.72 (95% CI 0.45-1.16) for men with high cytotoxic activity, and 0.62 (0.38-1.03) for men with medium cytotoxic activity, taking the risk of those with low cytotoxic activity as reference. For women with high cytotoxic activity relative risk was 0.52 (0.28-0.95), and for those with medium cytotoxic activity 0.56 (0.31-1.01). For both sexes with high and medium cytotoxic activity risk was 0.63 (0.43-0.92) and 0.59 (0.40-0.87), respectively.Interpretation Our results indicate that medium and high cytotoxic activity of peripheral-blood lymphocytes is associated with reduced cancer risk, whereas low activity is associated with increased cancer risk suggesting a role for natural immunological host defence mechanisms against cancer.