IDENTIFICATION AND PROBABLE ROLE OF A SINGLE NEURON CONTAINING THE NEUROPEPTIDE HELIX FMRFAMIDE
IDENTIFICATION AND PROBABLE ROLE OF A SINGLE NEURON CONTAINING THE NEUROPEPTIDE HELIX FMRFAMIDE
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DOI：
10.1038/304638a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
DOCKRAY, GJ
中科院分区：
文献类型：
--
作者：
COTTRELL, GA;SCHOT, LPC;DOCKRAY, GJ
最近，人们对肽可能充当神经递质的可能性产生了浓厚的兴趣1,2。尽管取得了很大进展，但仍然没有明确的例子表明化学特征肽的产生可以归因于已证明生理作用的个体可识别神经元/无脊椎动物系统已被证明对于已识别神经元的研究特别有价值，包括那些产生肽的神经元3,4。我们现在已经鉴定出螺旋神经节中的一个神经元，该神经元与 Phe-Met-Arg-Phe-NH2 (FMRFamide) 基团的肽相关，并且影响触手收缩。该系统首次提供了在系统中研究肽能传递的能力，在该系统中细胞体和突触后靶标都可以容易且可重复地识别。
Recently, there has been intense interest in the possibility that peptides might function as neurotransmitters1,2. Despite much progress, there remains no clear-cut example in which the production of a chemically characterized peptide may be ascribed to individual identifiable neurones of proven physiological role/Invertebrate systems have proved to be particularly valuable for the study of identified neurones, including those producing peptides3,4. We have now identified a neurone in ganglia ofHelixthat is associated with a peptide of the Phe-Met-Arg-Phe-NH2(FMRFamide) group, and which influences tentacle contraction. This system offers for the first time the capacity to study peptidergic transmission in a system in which both the cell soma and the postsynaptic target may be readily and reproducibly identified.