Stat3 is involved in the motility, metastasis and prognosis in lingual squamous cell carcinoma
Stat3 is involved in the motility, metastasis and prognosis in lingual squamous cell carcinoma
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DOI：
10.1002/cbf.2810
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发表时间：
2012-06
影响因子：
3.6
通讯作者：
Yan Zhao;Jiali Zhang;Haibin Xia;Bi Zhang;T. Jiang;Jiawei Wang;Xinmin Chen;Yining Wang
中科院分区：
文献类型：
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作者：
Yan Zhao;Jiali Zhang;Haibin Xia;Bi Zhang;T. Jiang;Jiawei Wang;Xinmin Chen;Yining Wang
信号转导和转录激活因子3（Stat3）已在许多类型的癌症中被检测到，并在肿瘤细胞存活，增殖，自我更新和侵袭中发挥重要作用。为了探讨Stat3可能参与舌鳞状细胞癌的转移和预后的可能性，我们检测了Stat3表达是否与人类临床样本的转移或生存率相关。Stat3的表达与胃癌的淋巴结转移（P = 0.009）、分期（P = 0.029）、复发（P = 0.0032）和死亡（P = 0.0356）有关。通过RNA干扰特异性敲低Stat3强烈抑制肿瘤细胞的运动和侵袭活性。我们的研究结果表明，Stat3参与了人舌鳞癌的运动，转移和发展，因此，它可能是一个人舌鳞癌的治疗靶点。版权所有© 2012约翰威利父子有限公司.
The signal transducers and activators of transcription 3 (Stat3) has been detected in many types of cancer and plays an important role in tumour‐cell survival, proliferation, self‐renewal and invasion. To address the possibility that Stat3 may be involved in the metastasis and prognosis in lingual squamous cell carcinoma, we examined whether Stat3 expression associates with metastasis or survival rate in human clinical samples. We found that there was a significant correlation between Stat3 expression and lymph node metastasis (P = 0.009), stages (P = 0.029), recurrence (P = 0.0032) and death (P = 0.0356). The specific knockdown of Stat3 by RNA interference strongly inhibited the motile and invasion activity of tumour cells. Our results suggest that Stat3 is involved in the motility, metastasis and progression in human lingual squamous cell carcinoma, and thus, it may be a therapeutic target for human lingual squamous cell carcinoma. Copyright © 2012 John Wiley & Sons, Ltd.