THE ACTIVITY OF THE SYMPATHETIC NERVOUS-SYSTEM FOLLOWING SEVERE HEAD-INJURY
THE ACTIVITY OF THE SYMPATHETIC NERVOUS-SYSTEM FOLLOWING SEVERE HEAD-INJURY
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DOI：
10.1007/bf01757299
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发表时间：
1980-01-01
影响因子：
38.9
通讯作者：
HORTNAGL, H
中科院分区：
文献类型：
--
作者：
HORTNAGL, H;HAMMERLE, AF;HORTNAGL, H
通过测量血浆肾上腺素和去甲肾上腺素水平，对15例严重闭合性颅脑损伤患者交感神经系统的活动进行了评估。随着中脑综合征向阴茎综合征过渡阶段的开始，以去甲肾上腺素为主的血浆水平开始升高，并在疾病的进一步病程中保持高位。在卵巢综合征缓解期间，升高的去甲肾上腺素水平开始下降。数据表明，交感神经系统的长期过度活动是严重头部损伤过程中的一个特征。作为一种合理的治疗方法来保护外周组织免受长期交感神经过度活动的影响，我们建议使用β-肾上腺素能阻断剂和肾上腺素能神经元阻断药物。
The activity of the sympathetic nervous system during the course of severe closed head injury has been evaluated in 15 patients by measuring plasma levels of epinephrine and norepinephrine. With the onset of the transition stage from midbrain syndrome to the apallic syndrome the plasma levels mainly of norepinephrine started to increase and remained high during the further course of the disease. During the remission from the apallic syndrome the elevated norepinephrine levels started to decline. The data indicate that a longlasting overactivity of the sympathetic nervous system is a characteristic feature in the course of severe head injury.As a rational therapy to protect the peripheral tissues against the consequences of a longlasting sympathetic overactivity we suggest the use of β-adrenergic blocking agents and adrenergic neuron blocking drugs.