Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films
Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films
复制标题
DOI：
10.1016/j.aca.2011.02.042
复制
发表时间：
2011-05-23
影响因子：
6.2
通讯作者：
Kunitake, Toyoki
中科院分区：
文献类型：
--
作者：
Mizutani, Naoki;Yang, Do-Hyeon;Kunitake, Toyoki
通过在甲苯-乙醇混合物（1:1，v/v）中旋涂 Ti(O-Bu-n)(4) 溶液，在石英板上制备了带有普萘洛尔、1,1'-联萘酚和 2-(4-异丁基苯基)-丙酸印迹 (R)- 和 (S)- 对映体的 TiO2 纳米薄膜。去除模板后，印迹薄膜与原始模板的结合比与相应对映体的结合更好。通过紫外-可见光测量对模板掺入、模板去除和重新结合进行评估。通过优化薄膜厚度和对压印薄膜进行热处理，显着提高了对映选择性。扣除非特异性结合后，优化的薄膜提供了手性识别，(R)-普萘洛尔的对映选择性几乎为 100%，(S)-普萘洛尔的对映选择性为 95%。 (C) 2011 Elsevier B.V. 保留所有权利。
TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1'-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-Bu-n)(4) in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol. (C) 2011 Elsevier B.V. All rights reserved.