PROTON SPECTROSCOPY OF HUMAN STROKE - ASSESSMENT OF TRANSVERSE RELAXATION-TIMES AND PARTIAL VOLUME EFFECTS IN SINGLE VOLUME STEAM MRS
PROTON SPECTROSCOPY OF HUMAN STROKE - ASSESSMENT OF TRANSVERSE RELAXATION-TIMES AND PARTIAL VOLUME EFFECTS IN SINGLE VOLUME STEAM MRS
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DOI：
10.1016/0730-725x(94)90087-8
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发表时间：
1994-01-01
影响因子：
2.5
通讯作者：
PRICHARD, JW
中科院分区：
文献类型：
--
作者：
BLAMIRE, AM;GRAHAM, GD;PRICHARD, JW
测量了13例脑卒中患者和13例年龄匹配的正常人在2.1 t时的质子T-2松弛时间，使用蒸汽序列在8cc体积上获得光谱，回声时间（TE）分别为30.4 ms和270.0 ms，重复时间为2.8 s。横向松弛时间用两点计算估计。通过围绕梗死的自旋回波MRI测量STEAM体素中梗死的百分比体积，并与n-乙酰化化合物（NA）的峰值幅度相关。NA、肌酸、胆碱的T-2值在两组间无显著差异。乳酸患者的T-2分别为780±257 ms（平均±SE， n = 7）。在脑卒中患者中，NA绝对信号与正常脑部分体积对各频谱的贡献呈高度负相关（p < 0.001, r = 0.97）。再加上T-2不变，这表明NAA在梗死后24小时内从梗死组织中大部分消失。
Proton T-2 relaxation times were measured in 13 stroke patients and 13 aged-matched normal subjects at 2.1 T. Spectra were acquired from an 8-cc volume using the STEAM sequence with echo times (TE) of 30.4 ms and 270.0 ms and repetition time of 2.8 s. Transverse relaxation times were estimated using two-point calculations. Percentage volume of infarct in the STEAM voxel was measured on spin-echo MRI encompassing the infarct and correlated with the peak amplitude of N-acetylated compounds (NA). T-2 values of NA, creatine, and choline resonances showed no significant difference between patients and controls. T-2 for lactate in patients was 780 +/- 257 ms, respectively (mean +/- SE, n = 7). In stroke patients, high inverse correlation was found between the absolute NA signal and partial volume of normal brain contributing to each spectrum (p < .001, r = 0.97). Together with unchanged T-2, this suggests that NAA largely disappears from infarcted tissue within 24 hr postinfarct.