Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
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DOI：
10.1016/j.diabres.2004.11.007
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Yu, R
中科院分区：
文献类型：
--
作者：
Park, HS;Park, JY;Yu, R
目的：探讨血清中细胞因子C-反应蛋白（CR-P），肿瘤坏死因子（TNF）-α，白细胞介素（IL）-6，肥胖和内脏adiposity.Methods的浓度之间的关系：100名韩国成年人从预先存在的炎症性疾病或癌症进行了横断面研究。测量体重指数（BMI）、腰围和CRP、TNF-α和IL-6的血清浓度。在46例肥胖受试者中，脂肪量进行了评估，通过生物阻抗分析和腹部脂肪分布测定的计算机断层扫描scan.Results：总体而言，CRP，TNF-α和IL-6的血清浓度与体重，BMI，腰围，臀围，腰臀比显着相关。在肥胖者中，CRP和IL-6与BMI、腰围和内脏脂肪组织显著相关。多元回归分析显示，CRP与BMI显着相关，而IL-6与内脏肥胖在肥胖subjects.Conclusions：肥胖和内脏肥胖与细胞因子水平升高的正相关性表明，减少肥胖和内脏肥胖，以防止细胞因子水平升高的重要性。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
Objective: To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CR-P), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity.Methods: A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-alpha and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan.Results: Overall, serum concentrations of CRP, TNF-alpha and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects.Conclusions: The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels. (c) 2004 Elsevier Ireland Ltd. All rights reserved.