Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus
Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus
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小脑蚓部的攀爬纤维微区及其对前庭外侧核不同细胞群的投射
DOI：
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发表时间：
1978
影响因子：
2
通讯作者：
O. Oscarsson
中科院分区：
文献类型：
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作者：
G. Andersson;O. Oscarsson
1.在脊髓横断仅保留对侧腹索的猫，研究了脊髓腹侧棘突-橄榄小脑系统中的一条通路(b-VF-SOCP)到前叶前部外侧皮质b区和前庭外侧核(LVN)的投射。通过记录单个浦肯野细胞对刺激肢体神经的爬行纤维反应，研究向b区的投射。2.b区浦肯野细胞被随机分成5组，每组各有不同的输入，占据不同的微区，每个微区宽度约200μm。这些微区在穿过b区内侧时具有以下输入特征：1.仅来自后肢神经的激活，2.来自后肢神经的短潜伏期激活和来自前肢神经的长潜伏期激活，3.来自后肢和前肢神经的短潜伏期激活，4.来自前肢神经的短潜伏期激活和来自后肢神经的长潜伏期激活3.五个微区投射到不同群的LVN神经元，这些神经元在整个核内交织分布。投射到该微区的攀援纤维的侧支激活了来自某一微区的受抑制的LVN神经元。4.讨论了脊髓-橄榄-小脑-前庭-脊髓通路的组织。提示皮质下神经元的微区和集合体是小脑的基本计算单位。
Summary1.The projections from one of the paths (b-VF-SOCP) in the ventral spino-olivocerebellar system to the cortical b-zone located in the lateral part of the anterior lobe vermis and to the lateral vestibular nucleus (LVN) have been studied in cats with the spinal cord transected at C3 sparing only the contralateral ventral funiculus. The projection to the b-zone was studied by recording climbing fiber responses in single Purkinje cells on stimulation of limb nerves. The projections to the LVN, direct through climbing fiber collaterals and indirect through Purkinje cells, were studied by recording EPSPs and IPSPs in LVN neurons.2.The Purkinje cells in the b-zone were arbitrarily divided into five groups with different inputs and occupying different microzones each with a width of about 200 μm. On passing medially across the b-zone the microzones had the following input characteristics: 1. activation exclusively from hindlimb nerves, 2. short-latency activation from hindlimb and long-latency activation from forelimb nerves, 3. short-latency activation from hindlimb and forelimb nerves, 4. short-latency activation from forelimb and long-latency activation from hindlimb nerves, and 5. activation exclusively from forelimb nerves.3.The five microzones projected to different groups of LVN neurons which occurred intermingled throughout the nucleus. The LVN neurons inhibited from a certain microzone were activated by the collaterals of the climbing fibers projecting to that microzone.4.The organization of the spino-olivo-cerebello-vestibulo-spinal path is discussed. It is suggested that the microzone and collection of subcortical neurons represent the basic computational unit of the cerebellum.