Analysis of effects and pharmacokinetics of subcutaneously administered BDNF
Analysis of effects and pharmacokinetics of subcutaneously administered BDNF
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DOI：
10.1097/00001756-200104170-00040
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发表时间：
2001-04-17
期刊：
影响因子：
1.7
通讯作者：
Nakayama, C
中科院分区：
文献类型：
--
作者：
Kishino, A;Katayama, N;Nakayama, C
脑源性神经营养因子(BDNF)属于神经营养因子家族，已被证明是一种对运动神经元以及周围和中枢神经系统其他神经元有效的营养因子。然而，人们对S.C.的疗效和药代动力学之间的关系知之甚少。给予脑源性神经营养因子。本研究观察了脑源性神经营养因子对坐骨神经或面神经切断模型运动神经元的保护作用，并与血浆中脑源性神经营养因子的浓度进行了比较。在坐骨神经切断模型中，延迟治疗(在手术后1周开始)BDNF也被证明延缓了胆碱乙酰转移酶的降低。《神经报告》12：1067-1072(C)2001，Lippincott Williams&Wilkins.
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family and has been shown to be a potent and effective trophic factor for motor neurons and other neurons of the peripheral and central nervous. Little is known, however, about the relationship between the efficacy and pharmacokinetics of s.c. administered BDNF. In this study, the efficacy of BDNF on motor neuron protection in sciatic or facial nerve axotomy models was examined and compared with the concommitant concentrations of BDNF in plasma. Delayed treatment (started at I week after surgery) of BDNF was also shown to retard choline acetyltransferase reduction in sciatic nerve axotomy models. NeuroReport 12:1067-1072 (C) 2001 Lippincott Williams & Wilkins.