Vascular endothelial growth factors and vascular permeability.
Vascular endothelial growth factors and vascular permeability.
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DOI：
10.1093/cvr/cvq105
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发表时间：
2010-07-15
影响因子：
10.8
通讯作者：
Bates DO
中科院分区：
文献类型：
--
作者：
Bates DO
血管内皮生长因子（VEGF）是渗透性的关键调节因子。本文讨论了它们如何增加体内和体外血管通透性以及增加的后果的主要证据。对已发表文献的详细分析表明，体内和体外VEGF介导的渗透性在其时间过程上不同，但共同涉及许多特定的信号传导途径，特别是VEGF受体-2活化、通过瞬时受体电位通道的钙内流、磷脂酶C γ活化和一氧化氮合酶的下游活化。内皮型一氧化氮合酶的下游途径似乎涉及鸟苷酸环化酶介导的Rho-Rac途径的激活，以及随后涉及的连接信号蛋白，如血管内皮钙粘蛋白和紧密连接蛋白coccludens和occludin连接到肌动蛋白细胞骨架。信号似乎是协调通过空间组织的级联成一个signalplex，并认为为什么这可能是重要的参数。许多蛋白质已被确定为参与VEGF对血管通透性的调节，但这些蛋白质被认为通过相互作用来控制通透性的机制仍然依赖于实验系统，现有数据的综合显示，在完整的血管中，这些途径的协调仍然不清楚。
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-mediated permeability differs in its time course, but has common involvement of many specific signalling pathways, in particular VEGF receptor-2 activation, calcium influx through transient receptor potential channels, activation of phospholipase C gamma and downstream activation of nitric oxide synthase. Pathways downstream of endothelial nitric oxide synthase appear to involve the guanylyl cyclase-mediated activation of the Rho–Rac pathway and subsequent involvement of junctional signalling proteins such as vascular endothelial cadherin and the tight junctional proteins zona occludens and occludin linked to the actin cytoskeleton. The signalling appears to be co-ordinated through spatial organization of the cascade into a signalplex, and arguments for why this may be important are considered. Many proteins have been identified to be involved in the regulation of vascular permeability by VEGF, but still the mechanisms through which these are thought to interact to control permeability are dependent on the experimental system, and a synthesis of existing data reveals that in intact vessels the co-ordination of the pathways is still not understood.
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影响因子：
4
作者：
Dejana, Elisabetta;Orsenigo, Fabrizio;Lampugnani, Maria Grazia
通讯作者：
Lampugnani, Maria Grazia
影响因子：
3.3
作者：
Reddy, Sai T.;Berk, David A.;Swartz, Melody A.
通讯作者：
Swartz, Melody A.
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
DOI：
10.1161/01.atv.0000231518.86795.0f
发表时间：
2006-08-01
影响因子：
8.7
作者：
Cheng, H. -W.;James, A. F.;Bates, D. O.
通讯作者：
Bates, D. O.
影响因子：
20.3
作者：
Clauss, M;Sunderkötter, C;Risau, W
通讯作者：
Risau, W