Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats
Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats
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DOI：
10.1016/j.jpsychires.2009.12.010
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发表时间：
2010-08-01
影响因子：
4.8
通讯作者：
Nobrega, Jose N.
中科院分区：
文献类型：
--
作者：
Hamani, Clement;Diwan, Mustansir;Nobrega, Jose N.
胼胝体下扣带回（SCG）脑深部电刺激（DBS）目前正在研究作为一种治疗抑郁症。尽管最初的临床系列研究结果令人鼓舞，但仍有几个问题没有得到回答，包括最有效的刺激参数（即，电流强度和频率）以及单侧刺激是否也有益。我们最近发现，一些SCG DBS的影响可以模拟通过刺激腹内侧前额叶皮层（vmPFC）的大鼠进行强迫游泳测试（FST）。在这里，我们调查是否在一些DBS参数的变化，包括电极放置，影响结果在这个范例。总体而言，我们发现DBS的抗抑郁样作用随刺激设置和靶点的变化而变化。在200 μ A的电流强度下观察到最强的响应，其次是100 μ A和300 μ A。相比之下，400 μ A没有产生效果。使用200 μ A，130 Hz的频率比20 Hz更有效。一个有趣的发现是，左侧单侧刺激与双侧DBS一样有效。当考虑vmPFC内的不同靶点时，PL DBS后观察到显著的抗抑郁样反应，而IL刺激与不动评分的非显著降低相关。总之，高频率和中等强度的vmPFC DBS导致FST的最大反应。(c)2010爱思唯尔有限公司保留所有权利。
Subcallosal cingulate gyrus (SCG) deep brain stimulation (DBS) is currently being investigated as a treatment for major depression. Despite the encouraging findings of the initial clinical series, several questions remain unanswered, including the most effective stimulation parameters (i.e., current intensity and frequency) and whether unilateral stimulation is also beneficial. We have recently found that some of the effects of SCG DBS could be modeled by stimulating the ventromedial prefrontal cortex (vmPFC) of rats undergoing the forced swim test (FST). Here we investigate whether changes in a number of DBS parameters, including electrode placement, influence outcome in this paradigm. Overall, we found that the antidepressant-like effects of DBS varied as a function of stimulation settings and target. The strongest response was observed with a current intensity of 200 AA, followed by 100 mu A, and 300 mu A. In contrast, 400 mu A produced no effect. Using 200 mu A, a frequency of 130 Hz was more effective than 20 Hz. An intriguing finding was that left unilateral stimulation was as effective as bilateral DBS. When different targets within the vmPFC were considered, a significant antidepressant-like response was observed after PL DBS, whereas IL stimulation was associated with a non-significant reduction in immobility scores. In summary, vmPFC DBS at high frequency and moderate intensity led to a maximal response in the FST. (c) 2010 Elsevier Ltd. All rights reserved.