Structural and Functional Patterns in Healthy Aging, Mild Cognitive Impairment, and Alzheimer Disease
Structural and Functional Patterns in Healthy Aging, Mild Cognitive Impairment, and Alzheimer Disease
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DOI：
10.1097/wad.0b013e3181aba730
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发表时间：
2010-01-01
影响因子：
2.1
通讯作者：
Ortiz, Tomas
中科院分区：
文献类型：
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作者：
Besga, Ariadna;Ortiz, Laura;Ortiz, Tomas
本研究的目的是分析磁共振成像和脑磁图（MEG）的联合诊断轻度认知功能障碍（MCI）和AD的贡献。从三个诊断组：阿尔茨海默病（AD），MCI和对照组获得全头MEG记录。磁共振成像体积数据的全球大脑，颞叶，海马体积，也获得了。结果表明，海马结构的体积减少允许AD和MCI患者与对照组相比的歧视。AD组与对照组的正确分类率为91.3%，MCI组与对照组的正确分类率为83.3%。MEG数据显示AD患者比MCI和对照组表现出更高的θ和δ活性。这种更高的活动是显着的顶叶，颞叶和枕叶地区。对照组与MCI组左顶θ分类正确率为78.3%。右枕θ和左顶叶δ可区分正常人和AD患者，正确分类率为81.8%。左顶叶θ角对AD和MCI的正确分类率为56.6%。此外，这两种技术的结合显着提高了正确分类率，从而表明，多学科的技术角度可以提高诊断能力。
The aim of this study was to analyze the combined contribution of magnetic resonance imaging and magnetoencephalography (MEG) to the diagnosis of mild cognitive impairment (MCI) and AD. To whole-head MEG recordings were obtained from three diagnosis groups: Alzheimer disease (AD), MCI, and control. Magnetic resonance imaging volumetric data of global brain, temporal lobe, and hippocampal volumes, were also obtained. Results indicated that a reduction of volume in the hippocampal structure allowed the discrimination between AD and MCI patients as compared with controls. The percentage of correct classification was 91.3% when AD versus controls was compared, and 83.3% when we compared MCI versus control. MEG data showed that AD patients exhibit higher theta and delta activity than MCI and controls. Such higher activity was significant in parietal, temporal, and occipital areas. Left parietal theta classified controls versus MCIs with 78.3% rate of correct classification. Right occipital theta and the left parietal delta allowed the discrimination of controls versus ADs, with 81.8% rate of correct classification. Left parietal theta discriminated between ADs and MCIs with 56.6% rate of correct classification. In addition, the combination of both techniques significantly improved the rate of correct classification, thus indicating that a multidisciplinary perspective of techniques may improve the diagnostic capabilities.