Examination of the role of galectins in intestinal inflammation.
Examination of the role of galectins in intestinal inflammation.
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DOI：
10.1007/978-1-4939-1396-1_15
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发表时间：
2015
影响因子：
--
通讯作者：
A. Nishida;C. Lau;A. Mizoguchi
中科院分区：
文献类型：
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作者：
A. Nishida;C. Lau;A. Mizoguchi
肠道提供了对抗超过万亿种肠道微生物的第一道防线，患有由感染性、自身免疫性、过敏性、神经性和缺血性机制引起的广泛的炎性病症。最近的数据表明，半乳糖凝集素在某些肠道炎症的发病机制中具有双重作用（保护作用与有害作用），突出了这一研究领域的重要性。肠道炎症研究的一个潜在问题可能是需要一些独特的技术。因此，我们在此描述了如何诱导肠道炎症以及如何从肠道中分离淋巴细胞、髓样细胞、滤泡细胞和上皮细胞群体以用于肠道炎症的研究。
The intestine, which provides the first line of defense against over trillion of enteric microorganisms, suffers from broad range of inflammatory conditions caused by infectious, autoimmune, allergic, neurological, and ischemic mechanisms. Recent data have suggested dual roles (protective versus deleterious) for galectins in the pathogenesis of some intestinal inflammations, highlighting the importance of this area of research. A potential problem with the research of intestinal inflammation may be the requirement of some unique techniques. Therefore, we herein describe how to induce intestinal inflammation and how to isolate lymphocyte, myeloid cell, follicular cell, and epithelial cell populations separately from the intestine for the study of intestinal inflammations.