A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor α promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes
A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor α promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes
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DOI：
10.1210/jc.2002-020506
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发表时间：
2003-06-01
影响因子：
5.8
通讯作者：
Tuomi, T
中科院分区：
文献类型：
--
作者：
Li, HY;Groop, L;Tuomi, T
Our previous results have suggested that genes outside the human leukocyte antigen (HLA) class II locus may affect the phenotype of type 2 diabetic patients from families with both type 1 and type 2 diabetes ( mixed type 1/2). To study whether the TNFalpha gene could be such a modifying gene, we studied TNFalpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects. The TNFalpha(308) AA/AG genotype frequency was increased in adult onset type 1 patients (55%, 69 of 126), but it was similar in type 2 patients from type 1/2 families (35%, 33/93) or common type 2 families (31%, 122 of 395), compared with controls (33%, 95/284; P
