The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia.
The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia.
复制标题
椎前交感神经节突触传递的复杂性和多样性。
DOI：
10.1016/0301-0082(85)90015-2
复制
发表时间：
1985
影响因子：
6.7
通讯作者：
Simmons,MA
中科院分区：
文献类型：
--
作者：
Simmons,MA
The sympathetic ganglia have traditionally been considered to serve as simple relay stations from the central nervous system to the peripheral visceral organs. In this role the adrenergic ganglionic neurons received impulses exclusively from cholinergic preganglionic neurons and relayed these impulses in a diffuse fashion to the viscera; no integrative functions were thought to occur in the ganglia. More recently, the sympathetic ganglia, in particular the prevertebral ganglia, have been found to have a much more complex organization and, accordingly, a more integrative function has been attributed to these structures.Several recent findings illustrate the complexity of synaptic transmission in the prevertebral sympathetic ganglia. Firstly, the prevertebral ganglia receive a number of inputs from multiple nerve trunks. Not all of these inputs originate in the preganglionic nuclei of the spinal cord; fibers also arise from cell bodies in the viscera. Secondly, afferent fibers with cell bodies in the dorsal root ganglia traverse and apparently effect synapses in the prevertebral ganglia. Thirdly, immunoreactivity to a number of neuropeptides has been observed in neuronal structures in these ganglia. Some of these peptides exert specific neurotransmitter-like effects at selected sites in the central and peripheral nervous systems and also in the prevertebral ganglia. Results such as these demonstrate that the prevertebral ganglia do not function solely to relay cholinergic preganglionic impulses from the spinal cord to the peripheral visceral organs, but that these ganglia are also involved in the integration of both centrally and peripherally originating synaptic information transmitted by both acetylcholine and noncholinergic transmitters. These findings, which have led to a re-evaluation of the traditional concepts of sympathetic neurotransmission, are discussed in detail here. The abbreviations used are listed at the beginning of the article.
