Emerging investigators series: sewer surveillance for monitoring antibiotic use and prevalence of antibiotic resistance: urban sewer epidemiology
Emerging investigators series: sewer surveillance for monitoring antibiotic use and prevalence of antibiotic resistance: urban sewer epidemiology
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DOI：
10.1039/c6ew00158k
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发表时间：
2016-01-01
影响因子：
5
通讯作者：
Bisceglia, Kevin J.
中科院分区：
文献类型：
--
作者：
Fahrenfeld, Nicole;Bisceglia, Kevin J.
下水道监测可能是流行病学的一个有用的工具，将受益于更好地了解微生物制剂和处方抗生素的命运在下水道系统的运输。本文综述了影响下水道系统中抗生素和抗生素耐药菌（ARB）负荷和归宿的因素。本文综述了抗生素和耐药菌的监测研究。然后，潜在的复杂下水道输入的作用（e。例如，在一个实施例中，卫生保健设施的存在下水道），并在抗生素和ARB的时间变化的证据进行审查。提出了抽样最佳做法的建议。最后，证据是在下水道衰减抗生素和衰减，生长和基因转移ARB。有潜力，但有限的证据表明，下水道作为水库的ARB增长和水平基因转移。这篇综述强调了需要更好地了解ARB在普通人群中的携带情况以及下水道过程对抗生素和ARB命运的影响。
Sewer surveillance may be a useful tool for epidemiology that would benefit from improved understanding of the fate of microbial agents and prescription antibiotics during conveyance in sewer systems. The aim of this review is to provide an overview of the factors affecting the loading and fate of antibiotics and antibiotic resistant bacteria ( ARB) in sewer systems. A review of surveillance studies for antibiotics and antibiotic resistant bacteria is presented. Then, the role of potentially complicating sewer inputs ( e. g., the presence of health care facilities in a sewershed), and evidence for temporal variations in antibiotics and ARB are reviewed. Recommendations for best practices for sampling are made. Finally, evidence is presented for in-sewer attenuation of antibiotics and attenuation, growth and gene transfer for ARB. There is potential for, but limited evidence of, sewers serving as a reservoir for ARB growth and horizontal gene transfer. This review highlights the need for better understanding of ARB carriage in the general population and the impact of in-sewer processes on the fate of antibiotics and ARB.