Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid Tissues
Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid Tissues
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DOI：
10.1038/jid.2011.198
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发表时间：
2011-11-01
影响因子：
6.5
通讯作者：
Kabashima, Kenji
中科院分区：
文献类型：
--
作者：
Egawa, Gyohei;Kabashima, Kenji
抗原呈递给T细胞对于诱导适应性免疫是必不可少的。该事件不仅发生在淋巴结（LN）中，而且发生在皮肤中。最近使用Kaede转基因小鼠的体内贩运研究揭示，皮肤归巢效应记忆T细胞通过在皮肤中发生的抗原识别转变为中央记忆T细胞样表型来改变其效应功能和归巢能力。此外，这些细胞在皮肤和引流淋巴结之间来回移动。这些研究唤起了皮肤相关淋巴组织的经典概念，并强调了皮肤作为外周淋巴器官的关键作用。
Antigen presentation to T cells is essential for the induction of adaptive immunity. This event takes place not solely in the lymph node (LN) but also in the skin. Recent in vivo trafficking studies using Kaede-transgenic mice reveal that skin-homing effector memory T cells alter their effector function and homing ability by transitioning to a central memory T cell-like phenotype through antigen recognition that occurs in the skin. In addition, these cells travel back and forth between the skin and draining LNs. These studies are evocative of the classic concept of skin-associated lymphoid tissues and underscore the critical role of skin as a peripheral lymphoid organ.