An amnesty for unpublished trials
An amnesty for unpublished trials
复制标题
对未发表的审判的特赦
DOI：
10.1136/bmj.315.7109.622
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
I. Roberts
中科院分区：
文献类型：
--
作者：
Richard Smith;I. Roberts
本月，全球 100 多家医学期刊邀请读者发送有关未发表试验的信息。这次特赦应该会给患者带来重要的好处。为什么？
正确进行的随机对照试验的报告是有效医疗保健的基础，但许多试验并未提交发表。1 2 这降低了系统评价检测中等但具有临床意义的治疗效果的能力。因此，患者可能无法获得有效的医疗保健。第二个问题是，由于更有可能提交显示更有希望效果的试验，因此研究综合可能会给出有关有效性的误导性结论。因此，患者可能会接触到无用的或……
This month over 100 medical journals around the world are inviting readers to send information on unpublished trials. This amnesty should have important benefits for patients. Why?
Reports of properly conducted randomised controlled trials are the foundation of effective health care, but many are not submitted for publication.1 2 This reduces the power of systematic reviews to detect moderate but clinically important treatment effects. Patients may thus be denied effective forms of health care. A second problem is that since trials that show more promising effects are more likely to be submitted, research syntheses can give misleading conclusions about effectiveness. Patients may thus be exposed to useless or …