Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress
Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress
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DOI：
10.1016/j.biopsycho.2011.05.007
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发表时间：
2011-07-01
影响因子：
2.6
通讯作者：
Meinlschmidt, Gunther
中科院分区：
文献类型：
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作者：
Tegethoff, Marion;Raul, Jean-Sebastien;Meinlschmidt, Gunther
缺乏容易获得的胎儿应激生物学生物标志物。在这里，我们探讨是否量化的主要胎儿类固醇，脱氢表雄酮（DHEA）或硫酸脱氢表雄酮（DHEAS），液相色谱/串联质谱在婴儿指甲是一种工具，以评估胎儿应激生物学在怀孕期间母亲的压力生活事件。从80名婴儿（93%的提供样本的婴儿）中获得了足够的指甲（>= 1 mg）。母亲孕期有应激性生活事件的婴儿DHEA浓度升高（DHEA：F（1.41）= 6.105，P=0.018; DHEAS：F（1.77）= 0.767，P=0.384）。DHEA浓度与母亲孕前压力无关（F（1，41）= 0.010，P=0.922）。婴儿指甲DHEA可能是胎儿宫内暴露于母体应激的生物学相关性。该方法有望成为宫内应激生物学的第一个非侵入性回顾性生物标志物，为胎儿医学、内分泌学、产科、妇科的研究和临床应用以及了解健康和疾病的发育起源开辟了新的途径。(C)2011 Elsevier B. V.保留所有权利。
Easily accessible biomarkers for fetal stress biology are lacking. We here explore whether quantification of major fetal steroids, dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEAS), with liquid chromatography/tandem mass spectrometry in infant nails is a tool to assess fetal stress biology in response to maternal stressful life events during pregnancy. Sufficient nail (>= 1 mg) was available from 80 infants (93% of those providing samples). The concentration of DHEA, but not DHEAS, was increased in infants of mothers with stressful life events during pregnancy (DHEA: F(1.41) = 6.105, P=0.018; DHEAS: F(1.77) = 0.767, P=0.384). DHEA concentrations were not related to maternal stress before pregnancy (F(1,41) = 0.010, P=0.922). Infant nail DHEA may be a fetal biological correlate of intrauterine exposure to maternal stress. The method promises the first non-invasive retrospective biomarker for intrauterine stress biology, opening new ways for research and clinical applications in fetal medicine, endocrinology, obstetrics, gynecology, and for understanding the developmental origins of health and disease. (C) 2011 Elsevier B.V. All rights reserved.