Oxidative modulation of voltage-gated potassium channels.
Oxidative modulation of voltage-gated potassium channels.
复制标题
电压门控钾通道的氧化调节。
DOI：
10.1089/ars.2013.5614
复制
发表时间：
2014
影响因子：
6.6
通讯作者：
Heinemann,StefanH
中科院分区：
文献类型：
--
作者：
Sahoo,Nirakar;Hoshi,Toshinori;Heinemann,StefanH
Significance:Voltage-gated K+channels are a large family of K+-selective ion channel protein complexes that open on membrane depolarization. These K+channels are expressed in diverse tissues and their function is vital for numerous physiological processes, in particular of neurons and muscle cells. Potentially reversible oxidative regulation of voltage-gated K+channels by reactive species such as reactive oxygen species (ROS) represents a contributing mechanism of normal cellular plasticity and may play important roles in diverse pathologies including neurodegenerative diseases.Recent Advances:Studies using various protocols of oxidative modification, site-directed mutagenesis, and structural and kinetic modeling provide a broader phenomenology and emerging mechanistic insights.Critical Issues:Physicochemical mechanisms of the functional consequences of oxidative modifications of voltage-gated K+channels are only beginning to be revealed.In vivodocumentation of oxidative modifications of specific amino-acid residues of various voltage-gated K+channel proteins, including the target specificity issue, is largely absent.Future Directions:High-resolution chemical and proteomic analysis of ion channel proteins with respect to oxidative modification combined with ongoing studies on channel structure and function will provide a better understanding of how the function of voltage-gated K+channels is tuned by ROS and the corresponding reducing enzymes to meet cellular needs.Antioxid. Redox Signal.21, 933–952.
