Multimodal assessment of cortical activation during apple peeling by NIRS and fMRI
Multimodal assessment of cortical activation during apple peeling by NIRS and fMRI
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DOI：
10.1016/j.neuroimage.2003.12.003
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Dan, I
中科院分区：
文献类型：
--
作者：
Okamoto, M;Dan, H;Dan, I
神经成像的一个有趣的应用是直接测量日常生活中的实际人脑活动。为此，我们研究了苹果去皮过程中的皮层激活模式。我们首先进行了一项试点研究，以评估在苹果剥皮过程中的整个外侧皮层表面的激活模式，通过多通道近红外光谱（NIRS），并检测到大量的激活，除了预期的激活扩展到电机，运动前区和辅助运动区的前额叶区域。接下来，我们研究了皮质激活过程中模拟苹果去皮同时测量多通道近红外光谱和功能磁共振成像（fMRI）在四个科目。我们检测到运动区、前运动区和辅助运动区的激活，但前额叶皮层没有。因此，我们最后集中在前额叶皮层，并检查其激活过程中，苹果去皮12名受试者使用多通道近红外光谱。我们随后发现，在测量区域，其中包括部分背外侧，腹外侧和额极区的前额叶皮层的氧合血红蛋白的区域浓度显着增加。目前的研究表明，日常生活中的苹果剥可以激活前额叶皮层，但在功能磁共振成像环境中进行的不太费力的模拟苹果剥中可能检测不到这种激活。我们建议的重要性，皮质研究的日常任务，因为它是，但不是作为一个简化的形式，我们还建议的有效性，近红外光谱为此目的。对日常任务的研究可以作为理解人类皮层激活活动的垫脚石。(C)2004年爱思唯尔公司All rights reserved.
An intriguing application of neuroimaging is directly measuring actual human brain activities during daily living. To this end, we investigated cortical activation patterns during apple peeling. We first conducted a pilot study to assess the activation pattern of the whole lateral cortical surface during apple peeling by multichannel near-infrared spectroscopy (NIRS) and detected substantial activation in the prefrontal region in addition to expected activations extending over the motor, premotor and supplementary motor areas. We next examined cortical activation during mock apple peeling by simultaneous measurement using multichannel NIRS and functional magnetic resonance imaging (fMRI) in four subjects. We detected activations extending over the motor, premotor and supplementary motor areas, but not in the prefrontal cortex. Thus, we finally focused on the prefrontal cortex and examined its activation during apple peeling in 12 subjects using a multichannel NIRS. We subsequently found that regional concentrations of oxygenated hemoglobin significantly increased in the measured region, which encompassed portions of the dorsolateral, ventrolateral and frontopolar areas of the prefrontal cortex. The current study demonstrated that apple peeling as practiced in daily life recruited the prefrontal cortex but that such activation might not be detected for less laborious mock apple peeling that can be performed in an fMRI environment. We suggest the importance of cortical study of an everyday task as it is but not as a simplified form; we also suggest the validity of NIRS for this purpose. Studies on everyday tasks may serve as stepping stone toward understanding human activities in terms of cortical activations. (C) 2004 Elsevier Inc. All rights reserved.