Changes in Cytokines, Sensory Tests, and Self-reported Pain Levels After Manual Treatment of Low Back Pain
Changes in Cytokines, Sensory Tests, and Self-reported Pain Levels After Manual Treatment of Low Back Pain
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DOI：
10.1097/bsd.0000000000000231
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发表时间：
2017-07-01
影响因子：
1.9
通讯作者：
Stuart, Melissa K.
中科院分区：
文献类型：
--
作者：
Degenhardt, Brian F.;Johnson, Jane C.;Stuart, Melissa K.
Study Design: Unbalanced 3-factor design with repeated measures on 1 factor.Objective: To determine the effect of manual treatment (MT) on cytokine and pain sensations in those with and without low back pain (LBP).Summary of Background Data: Evidence suggests that MT reduces LBP but by unknown mechanisms. Certain cytokines have been elevated in patients with LBP and may be affected by MT.Methods: Participants aged 20-60 years with chronic LBP or without LBP were recruited and randomly assigned to MT, sham ultrasound treatment, or no treatment groups. Venous blood samples were collected and pain levels assessed at baseline, 1 hour later, and 24 hours later. Blood was analyzed for interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, and C-reactive protein. Pain levels were measured by pressure pain threshold (PPT), mechanical detection threshold (MDT), dynamic mechanical allodynia, and self-report.Results: Forty (30 women, age 36 +/- 11 y) participants completed the study, 33 with LBP (13 MT, 13 sham ultrasound treatment, and 7 no treatment) and 7 without LBP. Participants with or without LBP could not be differentiated on the basis of serum cytokine levels, PPT, or MDT (P >= 0.08). There were no significant differences between the groups at 1 hour or 24 hours on serum cytokines, PPT, or MDT (P >= 0.07). There was a significant decrease from baseline in IL-6 for the no treatment (LBP) group (P= 0.04), in C-reactive protein for the sham ultrasound treatment group (P= 0.03), in MDT for all 3 LBP groups (P
