Morphogenetic apoptosis: A mechanism for correcting discontinuities in morphogen gradients
Morphogenetic apoptosis: A mechanism for correcting discontinuities in morphogen gradients
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DOI：
10.1006/dbio.2002.0821
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发表时间：
2002-11-01
影响因子：
2.7
通讯作者：
O'Connor, MB
中科院分区：
文献类型：
--
作者：
Adachi-Yamada, T;O'Connor, MB
果蝇成虫盘的正常发育需要形态发生素Hh、Dpp和Wg的平滑梯度。在此，据报道，当在接收Dpp或Wg信号时在两个相邻细胞之间产生不连续时，则在不连续边界的任一侧上的细胞通过激活c-Jun N-末端激酶（JNK）途径而经历凋亡。此外，在翅盘的内侧区域，如果细胞没有接收到适当水平的Dpp和Hh信号，JNK通路也被激活。这些观察结果表明，在一个发展领域内的细胞有能力通过比较它们与它们的邻居接收到的形态发生信号的水平来访问它们的空间位置。这种现象可能与细胞竞争的过程有关，我们认为这是一种进化上重要的机制，有助于防止发育过程中异常的组织规格和生长。(C)2002 Elsevier Science（美国）。
Smooth gradients of the morphogens Hh, Dpp, and Wg are required for proper development of Drosophila imaginal discs. Here, it is reported that, when a discontinuity is generated between two adjacent cells in the reception of either the Dpp or Wg signal, then cells on either side of the discontinuity boundary undergo apoptosis by activating the c-Jun N-terminal Kinase (JNK) pathway. Furthermore, in the medial region of the wing imaginal disc, the JNK pathway is also activated if cells do not receive the proper levels of Dpp and Hh signals. These observations suggest that cells within a developing field have the ability to access their spatial positions by comparing the level of morphogen signal they receive with that of their neighbors. This phenomenon is likely related to the process of cell competition, and we suggest that it is an evolutionarily important mechanism that helps prevent abnormal tissue specification and growth during development. (C) 2002 Elsevier Science (USA).