24-HOUR GLUCOSE PROFILES DURING CONTINUOUS OR OSCILLATORY INSULIN INFUSION - DEMONSTRATION OF THE FUNCTIONAL-SIGNIFICANCE OF ULTRADIAN INSULIN OSCILLATIONS
24-HOUR GLUCOSE PROFILES DURING CONTINUOUS OR OSCILLATORY INSULIN INFUSION - DEMONSTRATION OF THE FUNCTIONAL-SIGNIFICANCE OF ULTRADIAN INSULIN OSCILLATIONS
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DOI：
10.1172/jci117817
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发表时间：
1995-04-01
影响因子：
15.9
通讯作者：
VANCAUTER, E
中科院分区：
文献类型：
--
作者：
STURIS, J;SCHEEN, AJ;VANCAUTER, E
在基础和刺激条件下，正常的胰岛素分泌振荡周期在ultradian 100-150分钟的范围内，为了验证振荡胰岛素输送比连续给药在降低血糖水平方面更有效的假设，在28小时期间，包括多导睡眠记录期间，对9名正常年轻男性进行了两次研究。内源性胰岛素分泌被生长抑素抑制，给予恒定的静脉内葡萄糖输注，外源性胰岛素以恒定速率或正弦模式输注120 min，当胰岛素以振荡模式输注时，28小时内的平均葡萄糖水平比输注速率恒定时低0.72 +/- 0.31 mmol/L振荡输注与恒定输注相比，白天的降血糖效果更显著，平均差异为1.04 ± 0.38mmol/L（P < 0.03）。尽管在两种情况下给予相同量的外源性胰岛素，但在振荡输注期间血清胰岛素水平往往低于恒定输注期间。超昼夜胰岛素振荡似乎促进更有效的葡萄糖利用。
Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range, To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min, The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05), The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions, Ultradian insulin oscillations appear to promote more efficient glucose utilizatio.