Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging Fischer 344 rats.
Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging Fischer 344 rats.
复制标题
衰老 Fischer 344 大鼠腹侧和背外侧前列腺叶中纤溶酶原激活剂的活性。
DOI：
10.1002/pros.2990160206
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Estensen,RD
中科院分区：
文献类型：
--
作者：
Wilson,MJ;Ditmanson,JV;Sinha,AA;Estensen,RD
测量不同年龄 Fischer 344 (F344) 大鼠腹侧和背外侧前列腺叶提取物中的纤溶酶原激活剂 (PA) 活性。与年轻动物相比，30 个月大动物的腹侧前列腺表现出广泛的上皮萎缩、一些炎症灶、腺内非典型增生和/或腺癌，并且 PA 活性显着增加。在酶谱中发现了低分子量和高分子量形式的激活剂，并且这两种形式的激活剂在 30 个月时均表现出增加。然而，老年大鼠的 PA 活性对阿米洛利抑制表现出更大的抵抗力，表明组织型激活剂活性比尿激酶的相对增加更大。在背外侧前列腺中没有观察到这些变化。激活剂活性的肺叶特异性变化似乎与不典型增生/肿瘤相关，而不是衰老。
Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30‐month‐old animals demonstrated widespread epithelial atrophy, some foci of inflammation, in‐traglandular atypical hyperplasia and/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low‐ and high‐molecular‐weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue‐type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe‐specific changes in activator activity appear related to dysplasia/neoplasia and not aging.