Antibiotic resistance in Salmonella spp. isolated from poultry: A global overview.
Antibiotic resistance in Salmonella spp. isolated from poultry: A global overview.
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DOI：
10.14202/vetworld.2020.2070-2084
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发表时间：
2020-10
期刊：
影响因子：
1.6
通讯作者：
Rondón-Barragán IS
中科院分区：
文献类型：
--
作者：
Castro-Vargas RE;Herrera-Sánchez MP;Rodríguez-Hernández R;Rondón-Barragán IS
肠道沙门氏菌是最重要的食源性致病菌，常与禽类产品污染有关。每年，沙门氏菌导致全球约9300万例胃肠炎和155，000例死亡。抗菌治疗是治疗这种细菌感染的首选;然而，由于人类医学和动物生产中抗生素的滥用，抗菌素耐药性已成为一个问题。据预测，到2050年，耐药病原体将导致全球约1000万人死亡，世界卫生组织建议需要迎来后抗生素时代。本综述的目的是讨论和更新沙门氏菌抗生素耐药性的现状，特别是其流行率，血清型和抗生素耐药性模式，以应对人类医学和家禽业中使用的关键抗菌药物。根据我们的综述，肉鸡、生鸡肉以及鸡蛋和产蛋鸡中沙门氏菌的中位患病率值分别为40.5%（四分位距[IQR] 11.5-58.2%）、30%（IQR 20-43.5%）和40%（IQR 14.2-51.5%）。最常见的血清型是肠炎沙门氏菌，其次是鼠伤寒沙门氏菌。在家禽生产链中，萘啶酸和氨苄青霉素的抗生素耐药性水平最高。这些发现强调了政府机构、家禽研究人员和生产者需要找到减少抗生素对家禽使用影响的方法，特别是要关注主动监测和寻找抗生素的替代品。
Salmonella enterica is the most important foodborne pathogen, and it is often associated with the contamination of poultry products. Annually, Salmonella causes around 93 million cases of gastroenteritis and 155,000 deaths worldwide. Antimicrobial therapy is the first choice of treatment for this bacterial infection; however, antimicrobial resistance has become a problem due to the misuse of antibiotics both in human medicine and animal production. It has been predicted that by 2050, antibiotic-resistant pathogens will cause around 10 million deaths worldwide, and the WHO has suggested the need to usher in the post-antibiotic era. The purpose of this review is to discuss and update the status of Salmonella antibiotic resistance, in particular, its prevalence, serotypes, and antibiotic resistance patterns in response to critical antimicrobials used in human medicine and the poultry industry. Based on our review, the median prevalence values of Salmonella in broiler chickens, raw chicken meat, and in eggs and egg-laying hens were 40.5% ( interquartile range [IQR] 11.5-58.2%), 30% (IQR 20-43.5%), and 40% (IQR 14.2-51.5%), respectively. The most common serotype was Salmonella Enteritidis, followed by Salmonella Typhimurium. The highest antibiotic resistance levels within the poultry production chain were found for nalidixic acid and ampicillin. These findings highlight the need for government entities, poultry researchers, and producers to find ways to reduce the impact of antibiotic use in poultry, focusing especially on active surveillance and finding alternatives to antibiotics.