Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women: A 24-month prospective study
Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women: A 24-month prospective study
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DOI：
10.1097/00005176-200111000-00011
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发表时间：
2001-11-01
影响因子：
2.9
通讯作者：
Selvaggi, L
中科院分区：
文献类型：
--
作者：
Ceci, O;Margiotta, T;Selvaggi, L
背景：人类免疫缺陷病毒(HIV)感染的母亲对丙型肝炎病毒(HCV)母婴传播进行了广泛的研究，而在HIV阴性的妇女中垂直传播的资料较少。方法：1995年1月至1997年6月，连续78名丙型肝炎病毒阳性/HIV阴性的妇女及其子女进入这项前瞻性研究，以确定丙型肝炎病毒垂直传播的患病率和危险因素。仔细寻找丙型肝炎病毒的危险因素，并在所有阳性母亲中测定丙型肝炎病毒载量和基因型。分别于出生时、出生后4、8、12、18、24个月进行丙氨酸氨基转移酶(ALT)和丙型肝炎病毒核糖核酸(HCV-RNA)检测。结果：60例丙型肝炎病毒阳性母亲所生婴儿中有8例(13.3%)感染了丙型肝炎病毒，但仅2例(3.3%)在随访结束时仍有感染。婴儿的基因分型与母亲的一致。在整个随访过程中，所有研究对象的ALT水平都在正常范围内。母体病毒载量高(P
Background: Mother to infant transmission of hepatitis C virus (HCV) has been extensively studied in mothers with human immunodeficiency virus (HIV) infection, whereas fewer data are available on the vertical HCV transmission in HIV-negative women.Methods: Between January 1995 and June 1997, 78 consecutive HCV-positive/HIV-negative women with their offspring entered this prospective study aimed to define the prevalence of and risk factors for HCV vertical transmission. Risk factors for HCV were carefully sought, and HCV viral load and genotype were determined in all positive mothers. The infants were tested for alanine aminotransferase (ALT) and HCV-RNA at birth and at 4, 8, 12, 18, and 24 months of age.Results: Eight of 60 (13.3%) infants born to HCV-RNA positive mothers acquired HCV infection, but only 2 (3,3%) were still infected by the end of follow-up. Infants' genotypes matched that of the mothers. ALT levels were in the normal range in all study subjects throughout the follow-up. High maternal viral load (P