Violent offenders respond to provocations with high amygdala and striatal reactivity.
Violent offenders respond to provocations with high amygdala and striatal reactivity.
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DOI：
10.1093/scan/nsx006
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发表时间：
2017-05-01
影响因子：
4.2
通讯作者：
Knudsen GM
中科院分区：
文献类型：
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作者：
da Cunha-Bang S;Fisher PM;Hjordt LV;Perfalk E;Persson Skibsted A;Bock C;Ohlhues Baandrup A;Deen M;Thomsen C;Sestoft DM;Knudsen GM
成功抑制冲动和愤怒情绪的能力是控制挑衅后的攻击性反应的基础。本研究的目的是检查神经反应挑衅和攻击使用实验室模型的反应性攻击。本研究采用一种新颖的功能性磁共振成像点减法攻击范式对44名男性进行了研究，其中18名是在押暴力罪犯，26名是对照非罪犯。我们测量了挑衅（金钱减法）后的大脑活动，而受试者有可能表现得咄咄逼人或追求金钱奖励。暴力犯罪者比对照组更具攻击性（攻击频率150比84，P = 0.03），杏仁核和纹状体对挑衅的脑部反应明显增强，杏仁核-前额叶和纹状体-前额叶的连通性降低。暴力犯罪者的杏仁核对挑衅的反应与任务相关行为呈正相关。在各组中，纹状体和前额叶对挑衅的反应与特质愤怒和特质攻击呈正相关。这些结果表明，暴力个体对社会挑衅表现出异常高的神经敏感性，这是一种与攻击行为相关的敏感性。这些发现为研究对挑衅敏感的神经通路提供了新的见解，这对于更有效地形成旨在减少病理性攻击行为的干预措施至关重要。
The ability to successfully suppress impulses and angry affect is fundamental to control aggressive reactions following provocations. The aim of this study was to examine neural responses to provocations and aggression using a laboratory model of reactive aggression. We used a novel functional magnetic resonance imaging point-subtraction aggression paradigm in 44 men, of whom 18 were incarcerated violent offenders and 26 were control non-offenders. We measured brain activation following provocations (monetary subtractions), while the subjects had the possibility to behave aggressively or pursue monetary rewards. The violent offenders behaved more aggressively than controls (aggression frequency 150 vs 84, P = 0.03) and showed significantly higher brain reactivity to provocations within the amygdala and striatum, as well as reduced amygdala-prefrontal and striato-prefrontal connectivity. Amygdala reactivity to provocations was positively correlated with task-related behavior in the violent offenders. Across groups, striatal and prefrontal reactivity to provocations was positively associated with trait anger and trait aggression. These results suggest that violent individuals display abnormally high neural sensitivity to social provocations, a sensitivity related to aggressive behavior. These findings provide novel insight into the neural pathways that are sensitive to provocations, which is critical to more effectively shaped interventions that aim to reduce pathological aggressive behavior.