Dopamine and Serotonin-Induced Modulation of GABAergic and Glutamatergic Transmission in the Striatum and Basal Forebrain.
Dopamine and Serotonin-Induced Modulation of GABAergic and Glutamatergic Transmission in the Striatum and Basal Forebrain.
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DOI：
10.3389/fnana.2017.00042
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发表时间：
2017
影响因子：
2.9
通讯作者：
Nishijo T
中科院分区：
文献类型：
--
作者：
Momiyama T;Nishijo T
近二十年来，纹状体和基底前脑（BF）中儿茶酚胺受体介导的多巴胺能或GABA能传递的调节已被广泛研究。在纹状体中，GABA能末梢中多巴胺（DA）D2受体的激活通过选择性阻断N型钙通道抑制GABA释放到胆碱能中间神经元上。在BF中，通过选择性阻断P/Q型钙通道，通过DA D1样受体抑制向胆碱能投射神经元的多巴胺能传递。另一方面，突触前抑制GABA释放到胆碱能神经元介导的D1样受体或5-HT 1B受体是独立的钙内流。此外，上述DA受体介导的钙内流依赖性突触前抑制随出生后发育而减弱，DA受体与各亚型钙通道之间的选择性偶联不变。此外，这些GABA能或谷氨酸能输入突触后神经元的精确起源可以通过最近的光遗传学方法来确定。因此，在特定的突触连接在纹状体和BF的某些类型的神经元之间的调制机制正在确定。
Catecholamine receptor-mediated modulation of glutamatergic or GABAergic transmission in the striatum as well as basal forebrain (BF) has been intensively studied during these two decades. In the striatum, activation of dopamine (DA) D2 receptors in GABAergic terminals inhibits GABA release onto cholinergic interneurons by selective blockade of N-type calcium channels. In the BF, glutamatergic transmission onto cholinergic projection neurons is inhibited via DA D1-like receptors by selective blockade of P/Q-type calcium channels. On the other hand, presynaptic inhibition of the GABA release onto cholinergic neurons mediated by D1-like receptors or 5-HT1B receptors is independent of calcium influx. In addition, the DA receptor-mediated calcium influx dependent presynaptic inhibition mentioned above decreases with postnatal development, with selective coupling between DA receptors and each subtype of calcium channels being unchanged. Furthermore, the precise origin of these GABAergic or glutamatergic inputs to postsynaptic neurons can be identified by recent optogenetic approaches. Thus, modulatory mechanisms in specific synaptic connections between certain types of neurons in the striatum and BF are being identified.