The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
复制标题
C3H/HeJ 小鼠中有缺陷的 LPS 反应基因的遗传图谱。
DOI：
10.4049/jimmunol.120.2.422
复制
发表时间：
1978
影响因子：
4.4
通讯作者：
Benjamin A. Taylor
中科院分区：
文献类型：
--
作者：
James E. M. Watson;Kathleen Kelly;Michael T. Largen;Benjamin A. Taylor
在回交(C3H/Hej x C57BL/6J)F1×C3H/HeJ小鼠中，缺陷内毒素应答基因Lps的表达和主要尿蛋白(MUP-1)的表达一致地遗传，表明这些基因座存在遗传连锁。已知MUP-1与小鼠4号染色体上的棕色毛色位点连锁，因此LPs现在可以被分配到4号染色体上。MUP-1和LPs之间的重组频率估计为0.06+/-0.02。我们利用多联指(Ps)突变进一步将LPs定位在4号染色体上。Lps位于MUP-1和Ps之间。
The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ x C57BL/6J)F1 x C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 +/- 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.