Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis
Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis
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核传递蛋白α2 (KPNA2) 在人类肿瘤中的致癌作用：泛癌分析
DOI：
10.1016/j.compbiomed.2021.104955
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发表时间：
2021-10
影响因子：
7.7
通讯作者：
Hua Yang
中科院分区：
文献类型：
--
作者：
Yiming Sun;Wenjing Li;Xiaolong Li;Hong Zheng;Yuan Qiu;Hua Yang
背景KPNA 2是一种核输出蛋白，在肿瘤发生中起重要作用，是肿瘤学研究的一个新热点。尽管越来越多的支持证据，其重要性，没有泛癌分析，在多个数据库中，是可用于深入的数据挖掘的gene.MethodsTumor数据从癌症基因组图谱（TCGA）和基因表达综合（GEO）进行了探讨，以调查潜在的致癌作用KPNA 2。结果KPNA2在多种肿瘤组织中高表达，其表达与肿瘤患者的预后存在不同程度的相关性。cBioPortal报告称，R285* 的无义突变被认为是KPNA 2的主要致瘤性遗传改变，并在LUSC、STAD和CESC病例中发现。在几种癌症中发现S62的磷酸化增强，并且发现癌症相关成纤维细胞的浸润水平与ACC、BRCA、MESO、TGCT、THCA和THYM中的KPNA 2表达水平线性相关。进一步明确了KPNA 2 DNA甲基化与TCGA中各种肿瘤发病的相关性。KEGG和GO富集分析鉴定了KPNA 2的细胞周期、微管结合和微管蛋白结合功能。它提供了关于KPNA 2在肿瘤发生中的作用的全面理解，并强调了KPNA 2在癌症研究中的潜在靶向作用。
BackgroundKPNA2, a nuclear export protein that plays an important role in tumorigenesis, is an emerging hotspot target in oncology. Despite increasing supporting evidence of its importance, no pan-cancer analysis, across multiple databases, is available for in-depth data mining of the gene.MethodsTumor data from both The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to investigate the potential oncogenic roles of KPNA2. Diverse analytical methods were used to gain a full-scale understanding of KPNA2: gene expression, survival situations, genetic mutations, DNA methylation, sites of protein phosphorylation, immunocyte infiltration, and correlative cellular pathways.ResultsKPNA2 is highly expressed in many cancers, and different correlations exist between KPNA2 expression and prognosis of cancer patients. cBioPortal reported that a nonsense mutation of R285* was considered to be the primary tumorigenic genetic alteration to KPNA2 and was found in cases of LUSC, STAD, and CESC. Enhanced phosphorylation of S62 was found in several cancers and the level of infiltration of cancer-associated fibroblasts was found to be linearly correlated with KPNA2 expression levels in ACC, BRCA, MESO, TGCT, THCA, and THYM. Correlations between KPNA2 DNA methylation and the pathogenesis of various tumors in TCGA were further identified. KEGG and GO enrichment analysis identified cell cycle, microtubule binding, and tubulin binding functions for KPNA2.ConclusionThis is the first pan-cancer analysis focusing on KPNA2. It provides a comprehensive understanding about the role of KPNA2 in tumorigenesis and highlights the potential targeted role of KPNA2 for cancer study.
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分析基因表达和甲基化的微阵列数据，以鉴定非小细胞肺癌中的长非编码 RNA。
影响因子：
4.6
作者：
Feng N;Ching T;Wang Y;Liu B;Lin H;Shi O;Zhang X;Zheng M;Zheng X;Gao M;Zheng ZJ;Yu H;Garmire L;Qian B
通讯作者：
Qian B
影响因子：
5.2
作者：
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通讯作者：
Maxwell, Christopher A.
影响因子：
3.3
作者：
Cui, Xiangrong;Jing, Xuan;Wang, Hongwei
通讯作者：
Wang, Hongwei
影响因子：
3.6
作者：
Kubo, Norio;Araki, Kenichiro;Shirabe, Ken
通讯作者：
Shirabe, Ken
影响因子：
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作者：
Wang CI;Chen YY;Wang CL;Yu JS;Chang YS;Yu CJ
通讯作者：
Yu CJ