High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
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DOI：
10.1007/s13402-012-0079-3
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发表时间：
2012-06-01
影响因子：
6.6
通讯作者：
Langer, Rupert
中科院分区：
文献类型：
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作者：
Bauer, Karina;Nitsche, Ulrich;Langer, Rupert
背景热休克蛋白(HSPs)在多种肿瘤中的表达增加，并已被证明与肿瘤生物学行为有关。本研究旨在探讨HSP70、HSP60和HSP27在结肠癌中的表达。材料与方法应用免疫组织化学方法检测355例各期结肠癌组织芯片中HSP70、HSP60和HSP27的表达。结果HSP27、HSP60和HSP70的表达介于阴性和高表达之间。HSP27、HSP60和HSP70的表达与UICC的PT分期、有无淋巴结转移或远处转移、肿瘤分级无关。HSP70高表达与总生存期相关(p
Background The expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer.Material and methods HSP expression was determined by immunohistochemistry on a tissue microarray with 355 primary resected colon carcinomas of all stages. Expression patterns were correlated with pathologic features (UICC pTNM category, tumor grading) and survival.Results Expression of HSP27, HSP60 and HSP70 ranged from negative to high. There was no correlation between HSP27, HSP60 and HSP70 expression among each other and with UICC pT category, presence of lymph node or distant metastases or tumor grading. High HSP70 expression was associated with worse overall survival (p