Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life.

Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life.
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抑郁症治疗的药物遗传学指南和决策支持工具：应用于晚年。

DOI：
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发表时间：
2018
期刊：
Pharmacogenomics (London)
影响因子：
--
通讯作者：
C. Bousman
C. Bousman
中科院分区：
--
文献类型：
--
作者：
D. D. Chang;Harris A Eyreeuro;Ryan B. Abbott;M. Coudreaut;B. Baune;Jeffrey A. Shaman;H. Lavretsky;E. Lenze;D. Merrill;Ajeet B. Singh;B. Mulsant;C. Reynolds;D. Müller;C. Bousman

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晚期抑郁症（LLD）是一种主要的抑郁症，在60岁之后，LLD经常与抗抑郁药的反应相关，除了多种药物外，还可以通过新发现的临床效果来改善LLD的临床效果评论评估了LLD药物遗传学证据基库，以及将其纳入现有商业决策支持工具和临床药物遗传学指南的程度。
Late-life depression (LLD) is a major depressive disorder that affects someone after the age of 60 years. LLD is frequently associated with inadequate response and remission from antidepressants, in addition to polypharmacy. Pharmacogenetics offers a promising approach to improve clinical outcomes in LLD via new discoveries determining the genetic basis of response rates and side effects, as well as the development of tailored pharmacogenetic-based decision support tools. This invited review evaluates the LLD pharmacogenetic evidence base and the extent to which this was incorporated into existing commercial decision support tools and clinical pharmacogenetic guidelines.
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影响因子： --
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