Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
复制标题
海马 mu 受体介导 CA3 区域的阿片类药物强化。
DOI：
10.1016/0006-8993(91)91263-z
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发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Stein,L
中科院分区：
文献类型：
--
作者：
Stevens,KE;Shiotsu,G;Stein,L
Dependence on reinforcing chemicals is manifested when drug-seeking and drug-taking behaviors come to dominate the response repertoire. Clinical observations suggests that the craving and compulsive drug-seeking that characterize drug depedence are aroused by memories of the reinforcing drug experience. If so, a brain structure intimately associated with memory — the hippocampus — would be a plausible substrate for drug reinforcement effects. We report here that drug-naive rats rapidly learn to self-administer the opioid peptide dynorphin A in the CA3 region of hippocampus, and that this behavior is blocked by co-administration of the non-selective opiate antatgonist naloxone. Subsequent studies demonstrated that coadministration of the μ-, but not κ- or δ-opioid antoganists also blocked self-administration behavior. We conclude that μ-receptors in the CA3 region of hippocampus may be important target sites for opioid dependence.
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