Immune response to mutant neo-antigens
Immune response to mutant neo-antigens
复制标题
对突变新抗原的免疫反应
作者：
Rory J Geyer;Rebecca Tobet;R. Berlin;P. Srivastava
通过对肿瘤发生和肿瘤进展过程中出现的新抗原的免疫原性进行扩展观察，我们认为影响正常组织的体细胞突变也会导致新表位的产生。我们假设，至少在炎症条件下，针对这些新抗原的免疫应答可能导致正常细胞的消除或功能受损，从而导致衰老。
Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging.
DOI：
10.1073/pnas.0407780102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Basu, S;Srivastava, P
通讯作者：
Srivastava, P
体内肿瘤变异建模。
DOI：
10.1073/pnas.0401340102
发表时间：
2005
影响因子：
11.1
作者：
Stringer,JamesR;Larson,JonS;Fischer,JaredM;Medvedovic,Mario;Hersh,MeganN;Boivin,GregoryP;Stringer,SaundraL
通讯作者：
Stringer,SaundraL