The importance of the film structure during self-powered ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg
The importance of the film structure during self-powered ibuprofen salicylate drug release from polypyrrole electrodeposited on AZ31 Mg
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DOI：
10.1007/s10008-016-3288-2
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发表时间：
2016-12-01
影响因子：
2.5
通讯作者：
Walsh, F. C.
中科院分区：
文献类型：
--
作者：
Alshammary, B.;Casillas, N.;Walsh, F. C.
治疗药物上传到沉积在活性镁合金上的共轭导电聚合物基质中，作为控制剂量、自供电的药物输送系统。首先，尽可能多地将药物添加到聚合物薄膜中，主要是为了防止长期治疗。然而，添加的药物会与聚合物基体相互作用，影响聚合物薄膜的结构或最终力学性能。本文研究了聚吡咯薄膜（PPy）在含布洛芬和水杨酸溶液中电沉积在AZ31镁合金上的上载能力、表面形貌和力学性能。用于研究上传的PPy薄膜的技术包括循环伏安法（CV）、扫描电子显微镜（SEM）、能谱分析（EDS）和深度感测压痕（DSI）。在水杨酸钠存在下，PPy膜中布洛芬的最大浓度为440 +/- 40 μ g cm（-2）。布洛芬的释放分数随时间的变化符合Avrami方程。与仅在水杨酸钠中制备的薄膜相比，在布洛芬钠中制备的薄膜硬度和还原模量分别下降了54%和40%，表明布洛芬的存在使薄膜更具可塑性。
Therapeutic drugs uploaded into conjugated conductive polymer matrices deposited on active magnesium alloys serve as controlled-dose, self-powered drug-delivery systems. Preferentially, drugs are added into polymer films in the largest amount possible, mostly to prevent long-term treatments. However, added drugs can interact with the polymer matrix affecting either the structure or the final mechanical properties of the polymer film. In this work, polypyrrole films (PPy) electrodeposited on an AZ31 Mg alloy in ibuprofen and salicylate-containing solutions are investigated in terms of their uploading capacity, surface morphology and mechanical properties. The techniques used to investigate the uploaded PPy films include cyclic voltammetry (CV), scanning electron microscopy (SEM), EDS, and depth-sensing indentation (DSI). A maximum ibuprofen concentration of 440 +/- 40 mu g cm(-2) was obtained in PPy films in the presence of sodium salicylate. The release fraction of ibuprofen as a function of time is fitted to Avrami's equation. The hardness and reduced modulus decreased by 54 and 40 %, respectively, when the PPy films are prepared in the presence of sodium ibuprofen compared with those prepared in sodium salicylate only, indicating a more plastic film with ibuprofen.