Nanoporous sorbent material as an oral phosphate binder and for aqueous phosphate, chromate, and arsenate removal.
Nanoporous sorbent material as an oral phosphate binder and for aqueous phosphate, chromate, and arsenate removal.
复制标题
DOI：
10.4172/2157-7439.1000222
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Thanapon Sangvanich;Worapol Ngamcherdtrakul;Richard Lee;Jingga Morry;David J. Castro;G. Fryxell;W. Yanta
中科院分区：
文献类型：
--
作者：
Thanapon Sangvanich;Worapol Ngamcherdtrakul;Richard Lee;Jingga Morry;David J. Castro;G. Fryxell;W. Yanta
除磷对于生物和环境都很重要。从生物学角度来说，高磷血症是终末期慢性肾病患者的一种危急病症。高磷血症患者需要长期口服磷酸盐结合剂治疗，通过在胃肠道 (GI) 中捕获磷酸盐，然后通过粪便排泄来防止体内磷酸盐吸收。在环境方面，天然水资源中的磷酸盐含量必须根据美国环境保护局规定的限值进行监管。通过利用纳米技术和配体设计，我们开发了一种新材料来克服传统吸附剂材料的局限性，例如磷酸盐结合能力低、结合动力学慢以及其他阴离子的负面干扰。基于纳米多孔二氧化硅上的铁-乙二胺 (Fe-EDA-SAMMS) 的磷酸盐结合剂已针对基材和 Fe(III) 沉积方法进行了优化。与其他报告相比，Fe-EDA-SAMMS 材料的磷酸盐结合能力增加了 4 倍，并且操作 pH 范围更宽。该材料具有更快的磷酸盐结合率，并且与黄金标准口服磷酸盐结合剂 Sevelamer HCl 和市售阴离子交换剂 AG® 1-X8 相比，受其他阴离子的影响明显较小。它对 Caco-2 细胞的细胞毒性低于碳酸镧（另一种口服磷酸盐结合剂）。 Fe-EDA-SAMMS 还对砷酸盐和铬酸盐（天然水中两种毒性最强的阴离子）具有高容量。
Phosphate removal is both biologically and environmentally important. Biologically, hyperphosphatemia is a critical condition in end-stage chronic kidney disease patients. Patients with hyperphosphatemia are treated long-term with oral phosphate binders to prevent phosphate absorption to the body by capturing phosphate in the gastrointestinal (GI) tract followed by fecal excretion. Environmentally, phosphate levels in natural water resources must be regulated according to limits set forth by the US Environmental Protection Agency. By utilizing nanotechnology and ligand design, we developed a new material to overcome limitations of traditional sorbent materials such as low phosphate binding capacity, slow binding kinetics, and negative interference by other anions. A phosphate binder based on iron-ethylenediamine on nanoporous silica (Fe-EDA-SAMMS) has been optimized for substrates and Fe(III) deposition methods. The Fe-EDA-SAMMS material had a 4-fold increase in phosphate binding capacity and a broader operating pH window compared to other reports. The material had a faster phosphate binding rate and was significantly less affected by other anions than Sevelamer HCl, the gold standard oral phosphate binder, and AG® 1-X8, a commercially available anion exchanger. It had less cytotoxicity to Caco-2 cells than lanthanum carbonate, another prescribed oral phosphate binder. The Fe-EDA-SAMMS also had high capacity for arsenate and chromate, two of the most toxic anions in natural water.